clinic because of gastric malignancy found on a periodic medical check−up. He had no specific symptoms or signs. Physical examination and routine labora− tory studies were normal. Esophagogas− troduodenoscopy revealed early gastric cancer (EGC) in the antrum, and there was an additional reddish ulcer scar with fold convergence in the anterior wall of the duodenal bulb. Unlike typical ulcer scar...

Helicobacter pylori is an important risk factor for gastric cancer, gastric ulcer, and duodenal ulcer, yet most infected persons do not develop disease. We examined two correlates of acquisition age, sibship size and birth order, to evaluate the hypothesis that early life acquisition of //. pylori is a risk factor for the development of these illnesses. In earlier nested case-control studies of...

Maximal gastric secretion was induced in 122 control subjects (without peptic ulcer) and 201 preoperative duodenal ulcer patients by intravenous histamine acid phosphate (130 nmol/kg/h), and measured as Vg (ml/h) and MAO (mmol/h). In both groups, men secreted more than women, and smokers secreted more than non-smokers. Significant correlations were found between maximal gastric secretion on the...

AIM To assess the clinical characteristics of Helicobacter pylori (H pylori) negative duodenal ulcer. METHODS Patients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Patients were considered to be negative for H pylori, if both histological examination and rapid urease test of biopsy specimens were negative. A comparison was made betwe...

The number of G- and D-cells per area and the ratio of G/D-cells were investigated in biopsy specimens of the pyloric antrum from normochlorhydric subjects without peptic ulcer, from patients with duodenal ulcer, gastrinoma, pernicious anaemia, and after selective proximal vagotomy. Compared with normochlorhydric subjects antral G-cell density was significantly raised in pernicious anaemia, unc...

Background—Duodenal ulcer disease is strongly associated with Helicobacter pylori infection of the gastric mucosa. Eradication of H pylori from the gastric mucosa in adults is associated with long term healing of ulcers. Aims—To follow a cohort of children with duodenal ulcer disease for a minimum of two years after the eradication of H pylori. Patients and methods—Over a three year period, all...

BACKGROUND Duodenal ulcer disease is strongly associated with Helicobacter pylori infection of the gastric mucosa. Eradication of H pylori from the gastric mucosa in adults is associated with long term healing of ulcers. AIMS To follow a cohort of children with duodenal ulcer disease for a minimum of two years after the eradication of H pylori. PATIENTS AND METHODS Over a three year period,...

Although early studies attributed an important role to acid in the pathogenesis of duodenal ulcer pain, recent reports are conflicting. The aim of the present study is to determine whether direct acidification of the duodenal ulcer crater in symptomatic patients reproduces ucler pain. Patients with endoscopically diagnosed duodenal ulcers were studied. No premedication or sedation was given. A ...