Inhibitors of the renin-angiotensin system (RAS) form a cornerstone in the treatment of kidney disease. These drugs lower blood pressure and albuminuria, and afford renal protection. Dual therapy with an angiotensin-converting enzyme inhibitor and angiotensin receptor blocker have been shown to be more effective in reducing blood pressure and albuminuria than the single use of these agents. It ...

Myeloid differentiation primary response protein 88 (MyD88) has long been considered a central player in the inflammatory pathway. Recent studies clearly suggest that it is an important therapeutic target in inflammation. On the other hand, a recent study on the interaction between the orphan nuclear receptor (Nur77) and p38α, leading to increased lipopolysaccharide-induced hyperinflammatory re...

Various recent events have shown the enormous importance of maritime search-and-rescue missions. By reducing the time to find floating victims at sea, the number of casualties can be reduced. A major improvement can be achieved by employing autonomous aerial systems for autonomous search missions, allowed by the recent rise in technological development. In this context, the need for efficient s...

Analytical target cascading is a hierarchical multilevel multidisciplinary designmethodology. In analytical target cascading, top-level design targets (i.e., specifications) are propagated to lower-level design problems in a consistent and efficient manner. In this paper, a modified Lagrangian dual formulation and coordination for analytical target cascading are developed to enhance a formulati...

We report a fully covalent, dual-signalling electrochemical DNA sensor that exploits competitive binding and target hybridization-induced change in probe flexibility for simple and robust detection of target DNA.