spect detects γ-rays from administered radiopharmaceutical within the patient body. γ-rays pass through different tissues before reaching detectors and are attenuated. attenuation can cause artifacts; therefore different methods are used to minimize attenuation effects. in our study efficacy of chang method was evaluated for attenuation purpose, using a custom made heart phantom. due to differe...

SUBMITTED TO SIIM 2007 1 Increasing Accuracy of Mutual Information Based Registration of Tumor SPECT and CT Images with Dual-isotope Acquisition Lisa Tang∗, Ghassan Hamarneh∗, and Anna Celler† ∗Medical Image Analysis Lab, School of Computing Science, Simon Fraser University †Medical Imaging Research Group, Department of Radiology, University of British Columbia Hypothesis: Accuracy and robustne...

Carbonic anhydrase IX (CA IX) is currently generating great interest as a marker of tumour hypoxia and a potential chemotherapeutic target. In order to test the principle that a CA IX inhibitor could be used for targeting PET or SPECT metallic radioisotopes to tumours we have prepared a number of conjugates involving aryl-sulfonamides or an acetazolamide derivative linked to a range of copper, ...

Hybrid imaging techniques provide enhanced visualization of biological targets by synergistically combining multiple imaging modalities, thereby providing information on specific aspects of structure and function, which is difficult to obtain by a single imaging modality. Advances in the field of hybrid imaging have resulted in the recent approval of PET/magnetic resonance (MR) imaging by the U...

There is increasing clinical use of combined positron emission tomography and MRI, but to date there has been no clinical system developed capable of simultaneous single-photon emission computed tomography (SPECT) and MRI. There has been development of preclinical systems, but there are several challenges faced by researchers who are developing a clinical prototype including the need for the sy...

Whether a patient with head and neck cancer has mandibular invasion or not is important in determining the method of resection surgery. But, no modality is adequately reliable when used alone in the evaluation of mandibular invasion. Therefore, to more accurately diagnose mandibular invasion in head and neck cancer, we used a new modality, namely, 99mTc methylene diphosphonate (MDP) or 99mTc hy...

Introduction SPECT projections are contaminated by scatter radiation, resulting in reduced image contrast and quantitative errors. Backscatter constitutes a major part of the scatter contamination in lower energy windows. The current study is an evaluation of the effect of backscatter material on FWHM and image quality investigated by Monte Carlo simulation. Materials and Methods SIMIND program...