OBJECTIVE Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, the aim was to investigate the effects of emodin on EOC cells and to study further the mechanism underlying this process, both in vitro and in vivo. MAT...

We obtain several averaging lemmas for transport operator with a force term. These lemmas improve the regularity yet known by not considering the force term as part of an arbitrary right-hand side. We compare the obtained regularities according to the space and velocity variables. Our results are mainly in L 2 , and for constant force, in L p for 1 < p ≤ 2. Keywords: averaging lemma – force ter...

Although ursolic acid isolated from Oldenlandia diffusa (Rubiaceae) was known to have anticancer activities in prostate, breast and liver cancers, the underlying mechanism of ursolic acid in ovarian cancer cells was not investigated so far. In the present study, the apoptotic mechanism of ursolic acid was elucidated in SK-OV-3 ovarian cancer cells by 2,3-bis(2-methoxy-4-nitro-5-sulphophenyl)-2H...

In the ORTHOGONAL VECTORS (OV) problem, we wish to determine if there is an orthogonal pair of vectors among n Boolean vectors in d dimensions. TheOV Conjecture (OVC) posits that OV requires n time to solve, for all d = ω(logn). Assuming the OVC, optimal time lower bounds have been proved for many prominent problems in P, such as Edit Distance, Frechet Distance, Longest Common Subsequence, and ...

Orf virus (ORFV), a species of the genus Parapoxvirus of the family Poxviridae, causes non-systemic, highly contagious, and eruptive disease in sheep, goat, and other wild and domestic ruminants. Our previous work shows orf to be ubiquitous in the Fujian Province of China, a region where there is considerable heterogeneity among ORFVs. In this study, we sequenced full genomes of four Fujian goa...

Oncolytic viruses (OVs) target and destroy cancer cells while sparing their normal counterparts. These viruses have been evaluated in numerous studies at both pre-clinical and clinical levels and the recent Food and Drug Administration (FDA) approval of an oncolytic herpesvirus-based treatment raises optimism that OVs will become a therapeutic option for cancer patients. However, to improve cli...

Granulins are a family of protein growth factors that are involved in cell proliferation. An orthologue of granulin from the human parasitic liver fluke Opisthorchis viverrini, known as Ov-GRN-1, induces angiogenesis and accelerates wound repair. Recombinant Ov-GRN-1 production is complex and poses an obstacle for clinical development. To identify the bioactive region(s) of Ov-GRN-1, four trunc...

The systemic administration of oncolytic virus (OV) is often inefficient due to clearance of the virus by host defense mechanism and spurious targeting of non-cancer tissues through the bloodstream. Cell mediated OV delivery could hide the virus from host defenses and direct them toward tumors: Mesenchymal and neural stem cells have been described to possess tumor-homing ability as well as the ...

The aim of this paper is to solve the fixed point problems : v = Ov, with Ov(x) def = max(Lv(x), Bv(x)), x ∈ E , (1) where E is a finite set, L is contractive and B is a nonexpansive operator and v = Ov, with Ov(x) def = max(sup w Lv(x), sup z Bv(x)), x ∈ E , (2) where W and Z are general control sets, the operators L are contractive and operators B are nonexpansive. For these two problems, we ...

As cancer treatment tools, oncolytic viruses (OV) have yet to realize what some see as their ultimate clinical potential. In this study, we have engineered a chimeric vesicular stomatitis virus (VSV) that is devoid of its natural neurotoxicity while retaining potent oncolytic activity. The envelope glycoprotein (G) of VSV was replaced with a variant glycoprotein of the lymphocytic choriomeningi...