For the purposes of obtaining a hepatocyte-selective drug delivery system, a novel tetravalent galactosylated diethylenetriaminepentaacetic acid-distearoyl phosphatidylethanolamine (4Gal-DTPA-DSPE) was synthesized. The chemical structure of 4Gal-DTPA-DSPE was confirmed by proton nuclear magnetic resonance and mass spectrometry. The four galactose-modified liposomes (4Gal-liposomes) were prepare...

Introduction: In this study, organ radiation doses were calculated for the renal agent 99mTc-DTPA in children. Bio-kinetic energy of 99mTc-DTPA was evaluated by scintigraphy and estimates for absorbed radiation dose were provided using standard medical internal radiation dosimetry (MIRD) techniques.Material and Methods: In this applied research, fourteen children patients (6 males and 8 females...

The ability of the Modification of Renal Disease (MDRD) equation to predict GFR when compared with multiple other prediction equations in healthy subjects without known kidney disease was analyzed. Between May 1995 and December 2001, a total of 117 healthy individuals underwent (125)I-iothalamate or (99m)Tc-diethylenetriamine-pentaacetic acid (DTPA) renal studies as part of a routine kidney don...

Introduction: Clinical radiation nephropathy can result in considerable morbidity and/or mortality. Renal tolerance (TD5/5) has been stated to be 20 Gy when irradiation has been delivered to both kidneys in 3-5 weeks. Therefore to minimize renal toxicity in these patients, localization and shielding of the kidneys are essential. This study was carried out to evaluate the role of Tc-DTPA renal s...

BACKGROUND Evaluation of potential kidney donors requires the assessment of both kidney anatomy and function. In this prospective study, we sought to expand the diagnostic yield of magnetic resonance (MR) by adding functional measurements of glomerular filtration rate (GFR) and split renal function. METHODS Between 2007 and 2009, all potential kidney donors presenting to our facility underwen...

At 30 minutes after intravenous administration of the glomerular renal agent TC-99m-DTPA, both right and left lateral views were obtained. We analyzed the ratio of optical densities (behind the ureter/In front of the ureter). In patients without gross renal failure or retroperitoneal disease, the ratio was always less than 1 (range 0.38 to 0.95, mean 0.68). This represents greater perfusi...

Objective: To evaluate the improvement of renal function after pyeloplasty measured by 99mTc-DTPA renography. Materials and Methods: This hospital based quasi experimental study was done in department urology, National Institute Kidney Diseases Urology (NIKDU) Bangladesh Research Rehabilitation for Diabetes, Endocrine Metabolic Disorders (BIRDEM) from July 2014 to December 2020. Sixty patients ...

BACKGROUND Several late sequelae of the administration of gadolinium (Gd)-containing MRI contrast agents have been described in patients with advanced renal failure. In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for cardiovascular evaluation before renal transplantation. METHODS In a 26-month observational period, 13 of ...

BACKGROUND New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopen...