OBJECTIVE To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors. DESIGN Case-control study. SETTING Tertiary care cancer center. PATIENTS Two hundred one patients with DTC, 103 patients with benign thyroid tumors, and 680 cancer-free control subjects. MAIN OUTCOME MEASURES Resul...

objective(s): in clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (dtc) patients with high serum thyroglobulin (tg) and negative 131i whole-body scan (wbs) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. the purpose of this study was to evaluate the value of 18f-fdg pet/ct scan in dtc patients with high seru...

Objective(s): In clinical practice, approximately 10-25% of post-surgical differentiated thyroid carcinoma (DTC) patients with high serum thyroglobulin (Tg) and negative 131I whole-body scan (WBS) have poor prognosis due to recurrent or metastatic lesions after radioactive iodine treatment. The purpose of this study was to evaluate the value of 18F-FDG PET/CT scan in DTC patients with high seru...

Received Oct 27, 2011 Revised Jan 2, 2012 Accepted Mar 24, 2012 This paper presents a comparative study of field-oriented control(FOC), conventional direct torque control(DTC) and proposed space vector modulated direct torque control with low pass filter(SVM-DTC). The main characteristics of FOC, DTC and proposed SVM-DTC schemes are studied by simulation, emphasizing their advantages and disadv...

No clinical studies have investigated the effect of radioiodine (131I)-targeted therapy on neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) as inflammatory response markers in patients with differentiated thyroid cancer (DTC) associated type 2 diabetes mellitus (T2DM) obesity. This study aimed to assess relationship between blood radioactivity, body mass index (BMI), periph...

The serotonin 5-HT(3) receptor (5-HT(3)R) is a member of the cys-loop ligand-gated ion channel family. We have used the combination of site-directed mutagenesis, homology modeling of the 5-HT(3)R extracellular domain, and ligand docking simulations as a way to map the architecture of the 5-HT(3)R ligand binding domain. Mutation of Phe226 in loop C of the binding site to tyrosine (F226Y) has no ...

Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following entry of these antibiotics via the mechano-electrical transducer (MET) channels located at the tips of the hair cell's stereocilia. d-Tubocurarine (dT...

Well-differentiated thyroid cancer (DTC) is the most common form of thyroid cancer (TC); however, with the exception of radiation exposure, its etiology remains largely unknown. Several single nucleotide polymorphisms (SNPs) have previously been implicated in DTC risk. Nucleotide excision repair (NER) polymorphisms, despite having been associated with cancer risk at other locations, have receiv...

OBJECTIVE We aimed to measure prevalence of sleep disturbance in patients with differentiated thyroid cancer (DTC) by calculating Pittsburgh Sleep Quality Index (PSQI), and compare these data with patients with benign thyroid nodules or normal participants. METHODS Three groups of patients participated in this cross-sectional study. In the first group, 162 patients with DTC received total thy...

Differentiated thyroid carcinoma (DTC) of epithelium origin in children and adolescents is an uncommon malignancy with an excellent prognosis. However, pediatric DTC always presents at advanced stages and with higher rates of recurrence. This review aims at the current findings of etiology, diagnosis and therapeutic approach for pediatric DTC. Radiation exposure is the only established risk of ...