The molecular mechanism of many drug side-effects is unknown and difficult to predict. Previous methods for explaining side-effects have focused on known drug targets and their pathways. However, low affinity binding to proteins that are not usually considered drug targets may also drive side-effects. In order to assess these alternative targets, we used the 3D structures of 563 essential human...

Abstract Background Development of pharmaceutical interventions for schizophrenia emphasizes clinical efficacy and subsequent effectiveness cost-effectiveness. However, given the many side effects antipsychotic medication, it is important to consider importance different on preferences that people with have drugs. This study aims use a discrete choice experiment elicit patient medication profil...

conclusions there is a need to train health staff, and the community, concerning preventive measures, treatment, and reducing harm for substance drug users. results among 402 idus patients, a large amount of them were male, single, and younger than 39 years. regarding psychotic and somatic symptoms caused by methadone therapy, most of the participants had no problem with methadone maintenance t...

Therapeutic indications and drug side-effects are both measureable human behavioral or physiological changes in response to the treatment. In modern drug development, both inferring potential therapeutic indications and identifying clinically important drug side-effects are challenging tasks. Previous studies have utilized either chemical structures or protein targets to predict indications and...