A case of colchicine induced rhabdomyolysis is reported. A 73 year old man with ischaemic heart disease, atrial fibrillation, chronic congestive cardiac failure, and chronic gout presented with diVuse muscle pain. He had been taking an increased dose of colchicine (1.5 mg daily) for an exacerbation of gout for six weeks before the presentation. Investigations confirmed the diagnosis of rhabdomy...

Adverse drugs reactions (ADRs), put simply, are noxious, unintended, and undesirable effects that occur as a result of drug treatment at doses normally used in man for diagnosis, prophylaxis, and treatment. Although there are many terms indicating the harmful and undesirable effects of drug treatment, the term ‘adverse drug reaction’ describes them best. During the course of treatment, drugs pr...

BACKGROUND Drug reaction with eosinophilia and systemic symptoms is a severe form of drug-induced reaction with multiorgan involvement. OBJECTIVES The aim of this study is to evaluate the epidemiological, clinical and pathological features and prognosis of this drug reaction among patients seen at a dermatology service. METHOD Retrospective review of medical records of ten patients diagnose...

In this study, we describe a patient in whom tigecycline-induced drug fever and leukemoid reaction (LR) after 3 weeks of therapy for pneumonia.A 62-year-old man developed aspiration pneumonia on February 1, 2015. He had received multiple antibiotics at another hospital, but did not respond well. Disease rapidly progressed, and he was referred to our department on February 14. We adjusted the an...

Adverse drug reactions are responsible for mortality and morbidity during medical care. Spontaneous reporting of adverse drug reaction from treating physician plays an important role in assessing the benefit and risk profile of marketed drugs periodically.To assess the knowledge and attitude about adverse drug reaction reporting among the health care professionals working in a tertiary care hos...

A 57-year-old man was admitted to our hospital for evaluation and management of stroke in the setting of an atrial septal defect. Shortly after receiving gadobenate dimeglumine for magnetic resonance imaging of the pelvic vessels, he experienced cardiac arrest from which he was resuscitated. His course was complicated by profound distributive shock. The presumed cause was a severe anaphylactic ...

In the evaluation of patients with a history of adverse cutaneous drug reactions, it is important to obtain a detailed medication therapy including over-the-counter drugs, herbal and neuropathic remedies. There are a significant number of offending drugs causing adverse cutaneous drug reactions. If we can find out the clinical pattern of drug reaction along with their risk and aggravating facto...

BACKGROUND The purpose of this study was to investigate awareness among nurses regarding their new role as reporters of adverse drug reactions in Sweden and factors that may influence reporting by nurses. METHODS In 2007, all nurses were included in the adverse drug reaction reporting scheme in Sweden. A questionnaire was sent to 753 randomly selected nurses in September 2010. RESULTS Of th...

conclusions only a small number of case reports have described valproic acid-induced dress syndrome; therefore, the condition is difficult to prevent. rechallenge with valproic acid should be avoided in patients with a history of reaction to the drug. case presentation we report on the case of a 60-year-old man who had been treated with valproic acid some time before being referred to kowsar ho...