The interest in drug combinations is growing rapidly due to the opportunities they create to increase the therapeutic effect and to reduce the frequency or magnitude of undesirable side effects when single drugs fail to deliver satisfactory results. Considerable effort in studying the mechanisms leading to the benefits of the joint action of drugs has been matched by the development of relevant...

Finding effective drugs to treat fungal infections has important clinical significance based on high mortality rates, especially in an immunodeficient population. Traditional antifungal drugs with single targets have been reported to cause serious side effects and drug resistance. Nowadays, however, drug combinations, particularly with respect to synergistic interaction, have attracted the atte...

REVIEW ARTICLE Nanomedicine-Mediated Combination Drug Therapy in Tumor Dazhong Chen, Fangyuan Xie, Duxin Sun, Chuan Yin, Jie Gao and Yanqiang Zhong Department of Pharmaceutical Sciences, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Department of Pharmaceu...

the objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; eudragit rl 100 (eu rl) and cellulose acetate butyrate (cab) using the oil-in-oil emulsion solvent evaporation method. polymers were used separately and in combination to prepare different microcapsules. the effect of d...

Pharmaceutical differences between the reference listed drug (RLD) and generic formulations of piperacillin-tazobactam may impact the reconstitution process for intravenous administration. This study evaluated the RLD against three generic formulations and measured their reconstitution times using a standardized process. The mean (standard deviation [SD]) reconstitution time for one generic for...

A new European guideline on drug-eluting stents (DES) introduces for the first time detailed information that European drug authorities should review concerning the medicinal substance that is incorporated into this type of drug-device combination product. Part I of this article discussed European requirements that apply to DES. This article discusses the new guideline, other stent guidelines, ...