The maximum rate of pressure rise (dP/dtmax) in radial artery has been proposed as a noninvasive surrogate of aortic dp/dtmax, reflecting left ventricular (LV) contractility in children. The aim of this study was to investigate relationship between aortic and radial dp/dtmax at weaning from cardiopulmonary bypass (CPB) and usefulness of these indices for estimating postoperative outcomes in ped...

BACKGROUND The incidence of disability pension (DP) is high in several European countries. However, knowledge on associations of cause-specific DP and premature death is limited. The aims were to: 1) investigate the association between cause-specific DP and all-cause and cause-specific mortality among women and men and 2) examine period effects of this association. METHODS Three prospective p...

The conflicting results of recent pre-exposure prophylaxis (PrEP) trials utilizing tenofovir (TFV) to prevent HIV infection in women led us to evaluate the accumulation of intracellular TFV-diphosphate (TFV-DP) in cells from the female reproductive tract (FRT) and whether sex hormones influence the presence of TFV-DP in these cells. Following incubation with TFV, isolated epithelial cells, fibr...

Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...

The complexity of the coupling between soft particle deformation and fluid perturbation has limited studies of soft particle hydrodynamics to dilute suspensions. A hybrid Brownian dynamics-lattice Boltzmann method is presented that models nondilute soft spherical deformable particle (DP) suspensions in flow. Dependences on particle size and density are investigated for suspensions with over 100...

PURPOSE Surface disease is one of multiple variables affecting the quality of the postkeratoplasty donor cornea. Trauma to Bowman's layer before and during harvesting can denude the donor epithelium and result in epithelial defects in the donor following penetrating keratoplasty. Eye banks use death-to-preservation (DP) time intervals as long as 18 hours. This study evaluates the effects of hig...

STUDY DESIGN Retrospective cohort. OBJECTIVES In subjects with neck pain, the present study aimed (1) to describe the prevalence of centralization (CEN), noncentralization (non-CEN), directional preference (DP), and no directional preference (no DP); (2) to determine if age, sex, fear-avoidance beliefs about physical activity, number of comorbid conditions, or symptom duration varies among su...

In neonatal mouse skin, two types of dermal papilla (DP) are distinguished by Sox2 expression: CD133+Sox2+ DP are associated with guard/awl/auchene hairs, whereas CD133+Sox2- DP are associated with zigzag (ZZ) hairs. We describe a three-dimensional hydrogel culture system that supports clonal growth of CD133+Sox2+, CD133+Sox2-, and CD133-Sox2- (non-DP) neonatal dermal cells. All three cell popu...

CONTEXT Delayed puberty (DP) is a common issue and, in the absence of an underlying condition, is typically self limited. Alhough DP seems to be heritable, no specific genetic cause for DP has yet been reported. In contrast, many genetic causes have been found for idiopathic hypogonadotropic hypogonadism (IHH), a rare disorder characterized by absent or stalled pubertal development. OBJECTIVE...