New approach of breast cancer therapy is developed toward combination therapy with agent that have a specific molecular target. Our previous study showed that Citrus aurantifolia lime peels ethanolic extract (CPE) increased the sensitivity of MCF-7 cells againts doxorubicin. This study aims to observe the mechanism of combination CPE and doxorubicin in cell cycle modulation and apoptosis on MCF...

Background: Doxorubicin (DOX) is an anthracyclines antibiotic and is one of the most effective antitumor drugs. However, using this drug is associated with poisoning of healthy tissues. The purpose of this study was to investigate the changes in hematological parameters of male rats exposed to doxorubicin after eight weeks of high-intensity interval training and crocin consumption. Materials a...

Quercetin is one of the major flavonoids finding in many fruits and vegetables. Quercetin has many health promoting advantages such as improvement of allergic, arthritis disorder, and reduction of cancer and cardiovascular risk. The aim of this study was to examine hepatoprotective effects of quercetin on doxorubicin induced toxicity in animal model. Thirty male Wistar rats (200-230 g) were ran...

BACKGROUND Sildenafil, a phosphodiesterase-5 inhibitor, induces cardioprotection against ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels. It is unclear whether sildenafil would provide similar protection from doxorubicin-induced cardiotoxicity. METHODS AND RESULTS Male ICR mice were randomized to 1 of 4 treatments: saline, sildenafil, doxorubicin (5 mg/kg IP), and sil...

new approach of breast cancer therapy is developed toward combination therapy with agent that have a specific molecular target. our previous study showed that citrus aurantifolia lime peels ethanolic extract (cpe) increased the sensitivity of mcf-7 cells againts doxorubicin. this study aims to observe the mechanism of combination cpe and doxorubicin in cell cycle modulation and apoptosis on mcf...

The effect of lipopolysaccharide on doxorubicin-induced cell death was studied by using mouse RAW 264.7 macrophage cells. Pretreatment with lipopolysaccharide at 10 ng/mL prevented doxorubicin-induced cell death and the inhibition was roughly dependent on the concentration of lipopolysaccharide. Posttreatment with lipopolysaccharide for 1 hour also prevented doxorubicin-induced cell death. Lipo...

PURPOSE IMMU-110 is a drug immunoconjugate composed of doxorubicin conjugated to the humanized anti-CD74 monoclonal antibody, hLL1, at a doxorubicin/monoclonal antibody ratio of approximately 8:1 (mol/mol). CD74 is a rapidly internalizing molecule associated with HLA-DR, which has high expression by several tumor types. Here, we describe safety evaluations of IMMU-110 in mice and monkeys as wel...

BACKGROUND Doxorubicin has been shown to inhibit proliferation of cancer cells through proteolytic activation of CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor synthesized as a membrane-bound precursor. Upon doxorubicin treatment, CREB3L1 is cleaved so that the N-terminal domain of the protein can reach the nucleus where it activates transcription of genes that...

PURPOSE Doxorubicin is one of the most effective chemotherapeutic agents. However, up to 30% of the patients treated with doxorubicin suffer from congestive heart failure. The mechanism of doxorubicin cardiotoxicity is likely multifactorial and most importantly, the genetic factors predisposing to doxorubicin cardiotoxicity are unknown. On the basis of the fact that mtDNA lesions and mitochondr...

Doxorubicin has been used clinically to treat various types of cancer, and yet the molecular mode of actions of doxorubicin remains to be fully unraveled. In this study, we investigated the effect of doxorubicin on cultured ovarian cancer cells (CaOV3). MTT assay data showed that doxorubicin inhibits cell proliferation in a time- and dose-dependen...