Genetic, and indeed genomic, imprinting does occur in humans. This is manifest at the level of the genome, the individual chromosome, subchromosomal region or fragile site, or the single locus. The best evidence at the single gene level comes from a consideration of familial tumour syndromes. Chromosomal imprinting effects are revealed when uniparental disomy occurs, as in the Prader-Willi synd...

When Shakespeare bestows the name Michael Cassio on a character in Othello he would doubtless have been aware of some distinguised antecedents, including his friend Drayton and two other authors whom did not know personally but was fond reading, Michel de Montaigne Miguel Cervantes. Less immediately, several historical persons name, perhaps most notably Emperor Palaeologus, are mentioned number...

Ageing is doubtless complicated, lifelong process regarding many body systems, including endocrine system. Human hormonal system changes with age. Although these changes concern secretion of many hormones, they are not unidirectional, there are hormones secretion of which is diminished, whereas secretion of the others is augmented or not changed with age. A possible role of hormones which are o...

Sir,?I have pleasure in sending you a copy of a notice concerning the revision of the regulations for the Fellowship of the Royal College of Surgeons of England, with a copy of the new regulations. As the changes^ embodied in these regulations are possibly the most important that have been made since the Fellowship was instituted under the Charter of . 1843, it is hoped that you may be good eno...

"With reference to treatment, it will be noticed that ot the 83 cases, two absconded from the hospital, so that, practically, we have to deal with 81 instances of tetanus, and of these 13 are stated as having been " relieved" when discharged from hospital; this is doubtless a very unsatisfactory way of accounting for cases of tetanus, but it is unavoidable in this country ; the friends of the p...

In previous communications (1, 2, 3, 4, 5, 6) it has been shown that foreign substances, including a vital dye, a ferric salt, and a foreign protein, injected into an inflamed area were fixed in situ and failed to reach the regional lymphatic nodes as readily as under ordinary circumstances. When these same substances were injected into the circulating blood stream, they rapidly entered the sit...

Medical group practice in primary care remains comparatively undeveloped in France compared to other countries. In Finland and Sweden, doctors are grouped in local public structures with multidisciplinary teams, whereas in Canada, the Netherlands and the United Kingdom, they are organized in private units run by independent health professionals on a contractual basis. Among the factors explaini...

to become exclusively a medical institution focusing on curative procedures, and ultimately to expand its clientele to all levels of society. While large-scale involvement of medical men with hospitals doubtless preceded the administrative-institutional transformation of the latter (medical professionalization around the hospital clinic in France following the Revolution may have been one neces...

This paper reports the fabrication and testing of a helical cell separator that uses insulator-based dielectrophoresis as the driving force of its separation. The helical channel shape’s main advantage is its constant curvature radius which generates a constant electric field gradient. The presented separator was fabricated by extruding a sacrificial ink on rotating spindles using a computer-co...

Hospital, on the 6th May 1872, for barrenness. She has been married upwards of twelve years. She believes (doubtless erroneously) that up to the 7th year of her marriage she had had three miscarriages. During the last five years she hag certainly never conceived. She complains of much pain in the loins, and suffers from bearing down pains. Sexual congress lias always been accompanied by much pa...