DNA double-strand breaks (DSBs) are, arguably, the most deleterious form of DNA damage. An increasing body of evidence points to the inaccurate or inefficient repair of DSBs as a key step in tumorigenesis. Therefore, it is of great importance to understand the processes by which DSBs are detected and repaired. Clearly, these events must take place in the context of chromatin in vivo, and recent...

The response of climate to perturbations in GHGs is location dependent. Six experiments: control (CTRL); double CH4; double CO2; double N2O; halved CFC11 and halved CFC12 were carried out to reveal the local area response to different GHGs levels in the atmosphere over West Africa. Double CH4, CO2 and N2O generally induce wetness but they also induce localized dryness at the hilly and mountaino...

The response of climate to perturbations in GHGs is location dependent. Six experiments: control (CTRL); double CH4; double CO2; double N2O; halved CFC11 and halved CFC12 were carried out to reveal the local area response to different GHGs levels in the atmosphere over West Africa. Double CH4, CO2 and N2O generally induce wetness but they also induce localized dryness at the hilly and mountaino...