Background: When whole-body scintigraphy (WBS) is negative despite elevated serum thyroglobulin (Tg) levels, the value of FDG-PET in the diagnosis of recurrent and metastatic thyroid cancer is well documented. An experimental study by Petrich and colleagues (2002) showed that thyrotropin (TSH) levels >0.3 μg/L with equivocal or negative WBS showed an increased level of FDG uptake after recombin...

background: despite the relative success of surgical resection followed by proton, proton/photon, or conventional radiotherapy in terms of recurrence-free survival, chordomas are still associated with a high rate of recurrence. to our knowledge there are only very few reported cases of this rare tumor detected by f-18 fdg-pet. materials and methods: in this case we show the significance of f-18...

OBJECTIVES ¹⁸F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) is a less invasive diagnostic tool and promising in detecting gastrointestinal lesions of pediatric inflammatory bowel disease (IBD) patients. Co-registration of low-dose computed tomography (CT) could lead to improvements in the assessment of disease. Therefore, this retrospective study evaluates the value of PET±CT in ...

background: to retrospectively describe imaging characteristics of liver metastases on fused fdg-pet/ mri data sets and to compare the diagnostic accuracy of mri and fused fdg-pet/mri data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. materials and methods: 43 oncological patients (mean age: 56+/- 11 years) were investigated by fdg-pet/ct and l...

Introduction: The ability of quadratic dose protocol to maintain a good quality image for an overweight and obese patient is well reported. However, a practical approach to the implementation of this protocol in whole-body imaging in Malaysia is currently lacking. Hence, the aim of this study is to derive the quadratic dose formula that suits our PET system. Metho...

UNLABELLED The purpose of this study was to evaluate the feasibility of absolute quantification of regional cerebral glucose utilization (rCMR(glc)) in mice by use of (18)F-FDG and a small animal PET scanner. rCMR(glc) determined with (18)F-FDG PET was compared with values determined simultaneously by the autoradiographic 2-(14)C-DG method. In addition, we compared the rCMR(glc) values under is...

PURPOSE To evaluate 2-deoxy-2-[(18)F]fluoro-d-glucose positron emission tomography imaging ((18)FDG-PET) as a predictive, noninvasive, pharmacodynamic (PD) biomarker of response following administration of a small-molecule insulin-like growth factor-1 receptor and insulin receptor (IGF-1R/IR) inhibitor, OSI-906. EXPERIMENTAL DESIGN In vitro uptake studies of (3)H-2-deoxy glucose following OSI...

PURPOSE Assessing clinical activity of molecularly targeted anticancer agents, especially in the absence of tumor shrinkage, is challenging. To evaluate on-treatment 18F-fluorodeoxyglucose (FDG) and/or 18F-fluorodeoxythymidine (FLT) positron emission tomography (PET) for this purpose, we conducted a prospective multicenter trial assessing PET response rates and associations with progression-fre...

PURPOSE To study whether esophageal FDG activity changes by time of mid-course of fractionated radiotherapy (RT), and whether these changes are associated with radiation esophagitis in patients with non-small cell lung cancer (NSCLC). METHODS Fifty patients with stage I-III NSCLC were enrolled prospectively and, all received ≥60 Gy RT. FDG-PET/CT scans were acquired prior to, and during-RT af...

Objective(s): In this study, we aimed to describe the characteristics of portal vein tumor thrombosis (PVTT), complicating hepatocellular carcinoma (HCC) in contrast-enhanced FDG PET/CT scan. Methods: In this retrospective study, 9 HCC patients with FDG-avid PVTT were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT), which is a comb...