iii ACKNOWLEDGEMENTS First and foremost I owe my deepest gratitude to my advisor and mentor, Prof. David G. Taylor for mentoring me and supporting me throughout my thesis for the last one year. This thesis would not have been possible unless it was for his patience, motivation, enthusiasm and immense knowledge of the subject matter. Besides my advisor, I would like to thank Prof. Yorai Wardi fo...

The suggestion that transient states of primary adrenal hypofunction confined to salt conservation can occur in infancy has been most convincingly supported by Jaudon (1946, 1948). Many of his cases, however, showed varying combinations of hyperpigmentation, hypoglycaemia and acidosis, with some having diminished, and others increased, steroid excretion. On the other hand, in recent reports of ...

Most working parents face a common dilemma--how to care for their children when they are not in school but the parents are at work. In this article Kathleen Christensen, Barbara Schneider, and Donnell Butler describe the predictable and unpredictable scheduling demands school-age children place on working couples and single working parents. The authors assess the potential capacity of schools t...

2011 will mark the 30 anniversary of the first description of AIDS, and the 15 year since combination antiretroviral therapy (ART) was introduced. Since its introduction, ART has had profound impact on AIDS incidence and mortality in industrialized countries, and international collaboration, mainly through the Global Fund and the President’s Emergency Plan for AIDS Relief, has provided treatmen...

GENERAL ENDOCRINOLOGY. By C. Donnell Turner. W. B. Saunders Co., Philadelphia, 1948. xii + 604 pp. $6.75. This book is the first edition of a text-book on general endocrinology and is aimed to meet the needs of the beginning student in experimental endocrinology. Clearly, the book accomplishes this rather modest aim and more. It is not intended to be a completely adequate handbook for the advan...

In the course of evolution, man has acquired digestive enzymes that split complex food components to simpler, absorbable molecules, biosynthetic enzymes that reform complex body components and degradative enzymes that catabolize these components. Each enzyme is a protein and its biosynthesis is under genetic control. Mutation of the gene coded for the enzyme, or for one polypeptide where an enz...

Based on a recent theorem due to the authors, it is shown how the extreme tail dependence between an asset and a factor or index or between two assets can be easily calibrated. Portfolios constructed with stocks with minimal tail dependence with the market exhibit a remarkable degree of decorrelation with the market at no cost in terms of performance measured by the Sharpe ratio. Over a hundred...

Science and our Nation's Future: DL ARTHUR H. ALEXANDER and GRETA LANDWEHR. Deamination COMPTON ................... 207 of Amino Acids by the Human Oral Flora; Its Role The Concept of Integrative Levels and Biology: DR in Dental Caries Immunity: DR. ROBERT G. KESEL, ALEX B. NOVIKOFF ............. 209 JOSEPH F. 0 'DONNELL and ERNST R. KIRCH. The Obituary: Preparation of Highly Purified PR8 Influ...

The 1970s saw an explosion of clinical research in diabetes. In that decade the following was introduced: highly purified insulin, U-100 insulin, basal-bolus insulin therapy, selfmonitoring of blood glucose, glycosylated hemoglobin measurement, insulin pumps, laser photocoagulation, pancreas transplantation, the concept of specialized diabetes educators, and diabetes management teams. In 1975, ...