A method has been devised for serological tests with a virus producing rabbit papillomas that become carcinomatous. The discrete character of the growths caused by the virus when suitably diluted fits it notably for quantitative experimentation. It shows no tendency to lie latent in domestic rabbits though it does so on occasion in cottontails, the natural hosts. Sera which partially neutralize...

Mycobacterium tuberculosis in animals Humans have had a very close association with animals for millennia, utilising them for food, labour, transport, clothing, companionship, disability assistance, recreation, sport, religious and cultural icons, security, entertainment and research and in rescue, rehabilitation and conservation efforts. It is inevitable then that as a result of this close ass...

Although rabbits are common domestic pets, severe respiratory allergic reactions to rabbits in households are unusual. Ory c 1, a 17-kDa glycoprotein found in saliva and fur, has previously been identified as a major rabbit allergen. In this report, we describe the cases of three patients with rabbit allergy who presented with asthma and/or rhinitis while living in households with detectable le...

The immunological study of the Shope papilloma virus (1) has exceptional interest, for the virus causes enduring, proliferative growths that have the character of tumors (2). In the work now to be reported a complement fixation reaction has been used in addition to the neutralization test previously employed (3). Special attention has been paid to the relation of the virus and the complement-bi...

The virus of rabbit papillomatosis, a neoplastic disease studied intensively in relation to cancer because of its tendency toward malignant transformation, has been successfully transmitted by Aedes aegypti, Rhodnius prolixus, and Triatoma infestans from papillomas induced in cottontail rabbits, and by the first species mentioned, from papillomas induced in domestic rabbits. This was accomplish...

A method has been devised to determine the location of infective Shope virus in the papillomas of cottontail rabbits. Frozen sections of the growths were burned selectively with a microcautery to destroy either the keratinized or proliferating layer and the sections were then applied directly to the sensitized epidermis of domestic rabbits. No papillomas appeared when the keratohyaline and kera...