نتایج جستجو برای: dolutegravir
تعداد نتایج: 953 فیلتر نتایج به سال:
Objectives: The introduction of dual-therapy both as preferred starting therapy and in switches has been a revolution, allowing the same efficacy results to be obtained therapies with more Active Ingredients (AI) lower risk toxicity interactions. aim study is analyze efficacy, tolerability reasons for switching patients dolutegravir-based dual therapies.
The 2017 Conference on Retroviruses and Opportunistic Infections (CROI) featured exciting preclinical data on investigational antiretroviral agents with good in vitro efficacy and long half-lives. Investigational medications, including bictegravir, demonstrated excellent efficacy and tolerability, as did dual-agent therapy with dolutegravir paired with rilpivirine or with lamivudine. Dolutegrav...
The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are not all equal regarding genetic barrier to resistance. The aim of this manuscript was to review main in vivo and in vitro knowledge about two particular integrase resistance-associated mutations: R263K and E157Q. The R263K mutation was the first mutation rarely found selected at time of virological...
BACKGROUND Most of the previous studies that explored the molecular basis of raltegravir resistance were conducted studying the HIV-1 B subtype. It has been shown that the CRF02_AG subtype in relation to its natural integrase (IN) sequence could develop different genetic pathways associated with raltegravir resistance. The aim of this study was to explore resistance pathways preferably used by ...
Spectrophotometric methods were developed according to Quality by Design (QbD) approach as per ICH Q8(R2) guidelines for estimation of dolutegravir. QbD was carried out varying various parameters, and these variable parameters designed into Ishikawa diagram. The present work deals with the development sensitive, simple, accurate, precise cost-effective UV-spectrophotometric method determination...
A rapid, simple, sensitive and selective LC-MS/MS method has been developed validated for quanti? cation of the Dolutegravir Lamivudine in plasma samples. The analytical procedure involves a liquid–liquid extraction using Emtricitabine as an internal standard (IS). precision accuracy data have to fulfill requirements quantification analytes biological matrices generate bioequivalence bioavailab...
The thermal behavior of two polymorphic forms of rifampicin was studied by DSC and TG/DTG. The thermoanalytical results clearly showed the differences between the two crystalline forms. Polymorph I was the most thermally stable form, the DSC curve showed no fusion for this species and the thermal decomposition process occurred around 245 °C. The DSC curve of polymorph II showed two consecutive ...
Firing temperature Ancient Potteries are among the oldest and most significant technological innovations in the history of human achievement, and were the first truly synthetic material. Spectroscopic techniques are very useful tools to achieve a detailed knowledge of the art works. In the present study thermogravimetry (TG) and differential thermal analysis was carried out for pottery samples ...
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