In the present paper, an experimental assessment was performed on the transient thermal performance of a heat sink filled by a phase change material (PCM) and PCM embedded with carbon nanofibers (CNFs) and titania (TiO2) nanoparticles as nanostructured materials. In order to enhance the thermal conductivity of PCM, CNFs and TiO2 nanoparticles at different loadings (0.5wt. % and 2 wt.% of CNFs a...

This study aims to evaluate effects of two downscaling methods; change-factor and statistical downscaling on therunoff of the Azam-Harat River located at Yazd province (with an arid climate) of Iran, under the A2 emission scenariofor the period of 2010-2039. For this purpose, CGCM3-AR4 model; a rainfall-runoff conceptual model, IHACRES; twodownscaling models, Change Factor and LARS-WG were appl...

The solvated supermolecular approach, i.e., block-localized wave function coupled with polarizable continuum model (BLW/PCM), was proposed to calculate molecular ionization potential (IP), electron affinity (EA) in the solid phase, and related electronic polarization. Via the calculations of a solvated supermolecule (5M), including four closest molecules, BLW/PCM overcomes the limitation in the...

PURPOSE The clinical success of the first-in-class proteasome inhibitor bortezomib (VELCADE) has validated the proteasome as a therapeutic target for treating human cancers. MLN9708 is an investigational proteasome inhibitor that, compared with bortezomib, has improved pharmacokinetics, pharmacodynamics, and antitumor activity in preclinical studies. Here, we focused on evaluating the in vivo a...

Multi-model ensembles of climate predictions constructed by running several global climate models for a common set of experiments are available for impact assessment of climate change. Multi-model ensembles emphasize the uncertainty in climate predictions resulting from structural differences in the global climate models as well as uncertainty due to variations in initial conditions or model pa...

HIV-1 protease is one of the main therapeutic targets in HIV. However, a major problem in treatment of HIV is the rapid emergence of drug-resistant strains. It should be particularly helpful to clinical therapy of AIDS if one method can be used to predict antivirus capability of compounds for different variants. In our study, proteochemometric (PCM) models were created to study the bioactivity ...