نتایج جستجو برای: dna repair gene

تعداد نتایج: 1565035  

2017
L Dziki A Dziki M Mik I Majsterek J Kabzinski

Polymorphisms in DNA repair genes may affect the activity of the BER (base excision repair) and NER (nucleotide excision repair) systems. Using DNA isolated from blood taken from patients (n = 312) and a control group (n = 320) with CRC, we have analyzed the polymorphisms of selected DNA repair genes and we have demonstrated that genotypes 51Gln/His and 148Asp/Glu of APEX gene and 23Gly/Ala of ...

Journal: :Nucleic acids research 1998
K H Chen F M Yakes D K Srivastava R K Singhal R W Sobol J K Horton B Van Houten S H Wilson

DNA polymerase beta is required in mammalian cells for the predominant pathway of base excision repair involving single nucleotide gap filling DNA synthesis. Here we examine the relationship between oxidative stress, cellular levels of DNA polymerase beta and base excision repair capacity in vitro , using mouse monocytes and either wild-type mouse fibroblasts or those deleted of the DNA polymer...

Journal: :Cancer research 2011
Hai-De Qin Yin Yao Shugart Jin-Xin Bei Qing-Hua Pan Lina Chen Qi-Sheng Feng Li-Zhen Chen Wei Huang Jian Jun Liu Timothy J Jorgensen Yi-Xin Zeng Wei-Hua Jia

DNA repair plays a central role in protecting against environmental carcinogenesis, and genetic variants of DNA repair genes have been reported to be associated with several human malignancies. To assess whether DNA gene variants were associated with nasopharyngeal carcinoma (NPC) risk, a candidate gene association study was conducted among the Cantonese population within the Guangdong Province...

Journal: :Cancer research 1998
M R Shen I M Jones H Mohrenweiser

The removal or repair of DNA damage has a key role in protecting the genome of the cell from the insults of cancer-causing agents. This was originally demonstrated in individuals with the rare genetic disease xeroderma pigmentosum, the paradigm of cancer genes, and subsequently in the relationship between mismatch repair and colon cancer. Recent reports suggest that individuals with less dramat...

Journal: :Genes & development 1996
E L Beall D C Rio

The P family of transposable elements in Drosophila transpose by a cut-and-paste mechanism involving double-strand gap repair. We report here that a Drosophila mutagen-sensitive mutant, mus3O9, contains a mutation in IRBP (inverted repeat binding protein), the Drosophila homolog of the mammalian Ku p70 gene. We show that the repair of double-strand DNA breaks after P-element excision is severel...

2015
Pawel Bialk Natalia Rivera-Torres Bryan Strouse Eric B. Kmiec Hodaka Fujii

Single-stranded DNA oligonucleotides (ssODNs) can direct the repair of a single base mutation in human genes. While the regulation of this gene editing reaction has been partially elucidated, the low frequency with which repair occurs has hampered development toward clinical application. In this work a CRISPR/Cas9 complex is employed to induce double strand DNA breakage at specific sites surrou...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Shanthi Adimoolam James M Ford

The p53 tumor suppressor gene product is a transcription factor involved in cell-cycle regulation, apoptosis, and DNA repair. We and others have shown that p53 is required for efficient nucleotide excision repair (NER) of UV-induced DNA lesions. p53-deficient cells are defective in the repair of UV photoproducts in genomic DNA but proficient for transcription-coupled repair. Therefore, we exami...

2006
M. Richard Shen Irene M. Jones Harvey Mohrenweiser

The removal or repair of DNA damage has a key role in protecting the genome of the cell from the insults of cancer-causing agents. This was originally demonstrated in individuals with the rare genetic disease xeroderma pigmentosum, the paradigm of cancer genes, and subsequently in the relationship between mismatch repair and colon cancer. Recent re ports suggest that individuals with less drama...

2017
Geethakumari Konathala Ramesh Mandarapu Sudhakar Godi

X-ray repair cross-complementing group 1 (XRCC1) is a major DNA repair gene involved in BER mutation. Polymorphisms in DNA repair genes associated with repair efficiency against DNA damage may predispose an individual׳s cancer susceptibility. Data from cervical cancer patients was collected from South Indian Women. Genotyping of XRCC1 polymorphisms (194C/T, 280G/A and 399G/A) was done by polyme...

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