نتایج جستجو برای: dna repair

تعداد نتایج: 607978  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1990
C P Selby A Sancar

Caffeine potentiates the mutagenic and lethal effects of genotoxic agents. It is thought that this is due, at least in some organisms, to inhibition of DNA repair. However, direct evidence for inhibition of repair enzymes has been lacking. Using purified Escherichia coli DNA photolyase and (A)BC excinuclease, we show that the drug inhibits photoreactivation and nucleotide excision repair by two...

Journal: :Clinical chemistry 1995
L Grossman Q Wei

In a molecular epidemiological study of DNA repair, host reactivation assay was used to measure the DNA repair capacity of cryopreserved lymphocytes from 88 primary basal cell carcinoma (BCC) patients and 135 cancer-free controls. In this study population, reduced repair of ultraviolet radiation-induced DNA damage contributed to the risk of sunlight-induced BCC. A family history of BCC is assoc...

Journal: :Carcinogenesis 1997
R D Wood M K Shivji

There are five well-characterized nuclear DNA polymerases in eukaryotes (DNA polymerases alpha, beta, delta, epsilon and zeta) and this short review summarizes our current knowledge concerning the participation of each in DNA-repair. The three major DNA excision-repair pathways involve a DNA synthesis step that replaces altered bases or nucleotides removed during repair. Base excision-repair re...

Journal: :Science 2001
A Ronen B W Glickman

DNA repair systems are essential for the maintenance of genome integrity. Consequently, the disregulation of repair genes can be expected to be associated with significant, detrimental health effects, which can include an increased prevalence of birth defects, an enhancement of cancer risk, and an accelerated rate of aging. Although original insights into DNA repair and the genes responsible we...

Journal: :Oncotarget 2015

Journal: :Current Opinion in Genetics & Development 1997

Journal: :Biophysical Journal 2013

Journal: :Archives of Disease in Childhood 1998

Journal: :Journal of Cell Biology 2000

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