background: there are few studies indicating the detrimental effects of ibuprofen on sperm fertility potential and dna integrity. objective: to determine the effects of ibuprofen on sperm parameters, chromatin condensation and dna integrity of mice. materials and methods: in this experimental study, 36 adult male mice with average weight 37 gr were divided into three groups, including control (...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

Single crystals of B-DNA and Z-DNA oligomers were analyzed under high hydrostatic pressure their behavior was compared to the A-DNA already known. The amplitude base compression, when A-form DNA (0.13 Å/GPa), higher for (0.32 Å/GPa) highest (0.42 Å/GPa). crystal degraded rapidly around 400–500 MPa, while Z-structure more resistant, up 1.2 GPa.

We consider two models of interacting DNA molecules: First is (four parametric) bubble coalescence model in DNAs (shortly: BCI-DNA). Second (three a condensed molecules (shortly BCC-DNA). To study thermodynamics BCI-DNA and BCC-DNA we use methods statistical physics. Namely, define Hamiltonian each give their translation-invariant Gibbs measures (TIGMs). For the first model, find parameters suc...

The i-motif DNA, also known as i-DNA, is a non-canonical DNA secondary structure formed by cytosine-rich sequences, consisting of two intercalated parallel-stranded duplexes held together hemi-protonated cytosine–cytosine+ (C:C+) base pairs. growing interest in the i-DNA target anticancer therapy increases need for tools rapid and meaningful interpretation spectroscopic data samples. Herein, we...