BACKGROUND Currently, there is no cure for Duchenne and Becker muscular dystrophies (DMD/BMD). However, clinical trials with new therapeutic strategies are being conducted or considered. A comprehensive database is critical for patient recruitment and efficacy evaluation. China has the largest population, yet, no comprehensive database for DMD/BMD is available. Our study registered the data of ...

Fibrosis is a characteristic of Duchenne muscular dystrophy (DMD), yet the cellular and molecular mechanisms responsible for DMD fibrosis are poorly understood. Utilizing the Collagen1a1-GFP transgene to identify cells producing Collagen-I matrix in wild-type mice exposed to toxic injury or those mutated at the dystrophin gene locus (mdx) as a model of DMD, we studied mechanisms of skeletal mus...

Duchenne muscular dystrophy (DMD) causes progressive disability in 1 of every 5,000 boys due to the lack of functional dystrophin protein. Despite much advancement in knowledge about DMD disease presentation and progression-attributable in part to studies using mouse and canine models of the disease-current DMD treatments are not equally effective in all patients. There remains, therefore, a ne...

Pet owners desire treats with adequate nutritional profiles, functional benefits, long-lasting properties and an interactive nature. Therefore, it is pivotal to understand the digestion characteristics of treats produced by different processing methods and having variable nutritional composition. The objective of the present study was to measure in vitro disappearance characteristics of selecte...

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 125 Fogarty Hall, 41 Lower College Road, Kingston, RI 02881 (M.D., F.A.); Comparative and Molecular Pharmacogenomics Laboratory, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111 (M.H.C., S.H.). DMD # 36608 DMD ...

OBJECTIVE The aim of this study was to determine in pediatric Duchenne (DMD) and Becker muscular dystrophy (BMD) or other dilated cardiomyopathies (ODCM) whether outcomes differ by diagnosis. BACKGROUND Children with dilated cardiomyopathy are treated as a single undifferentiated group. METHODS This cohort study of 128 children with DMD, 15 with BMD, and 312 with ODCM uses outcome measures ...

We compared prediction of in vivo dry matter (DMD) and neutral detergent fiber (aNDFD) digestibility by the following techniques: (1) Tilley and Terry two-stage in vitro (conventional in vitro or IVDMD), (2) DaisyII in vitro (DaisyII), and (3) filter bag in situ preceded by 48 h acid–pepsin treatment. In addition, we also evaluated the effects due to sample size (0.25 g versus 0.50 g) and Wiley...

duchenne muscular dystrophy (dmd) and becker muscular dystrophy (bmd) can be caused by deletions, duplications or point mutations in the dmd gene that encodes dystrophin. partial gene duplications account for up to 5-10 % of dmd and up to 5- 19% of bmd cases. cases with gene duplication in dmd/bmd are determined by quantitative methods such as maph, sothern blotting and q-pcr that are laborious...

In this paper, differential modulation diversity (DMD) is introduced. This diversity scheme is based on diagonal signal constellations which have been previously proposed for differential space–time modulation (DSTM). DMD can exploit both space and time diversity and DSTM, which is a pure space diversity scheme, results as a special case. A low– complexity noncoherent receiver originally design...

DMD is a genetic X-linked recessive disease that affects approximately one in 3500 male births. Boys with DMD have progressive and predictable muscle destruction because of the absence of Dys, a protein present under the muscle fiber membrane. Dys deficiency induces contraction-related membrane damages, activation of inflammatory-necrosis-fibrosis up to the cardiac-diaphragmatic failure and dea...