254 Background: The addition of bevacizumab to capecitabine-based chemoradiotherapy (CRT) for LAPC has been shown to be safe. The aim of this study was to determine the safety, tolerability and maximum tolerated dose (MTD) of the addition of erlotinib to this treatment regimen. METHODS Seventeen patients with CT-staged biopsy-proven non-metastatic unresectable LAPC were enrolled between March...

O objetivo deste trabalho foi avaliar o efeito da utilização do dejeto líquido de suínos (DLS) e cama aves (CA) como fontes nitrogenadas na cultura feijoeiro. experimento conduzido em Frederico Westphalen (Estado Rio Grande Sul, Brasil), com delineamento experimental blocos casualizados sete tratamentos repetições. Foram testadas nitrogênio feijão, sendo uma mineral, ureia (M), duas orgânicas, ...

We study query answering in Description Logics (DLs). In particular, we consider conjunctive queries, unions of conjunctive queries, and their extensions with safe negation or inequality, which correspond to well-known classes of relational algebra queries. We provide a set of decidability, undecidability and complexity results for answering queries of the above languages over various classes o...

The correlation between molecular changes and microstructural evolution of rheological properties has been demonstrated for the first time in a mixed anionic/zwitterionic surfactant-based wormlike micellar system. Utilizing a novel combination of DLS-microrheology and Raman Spectroscopy, the effect of electrostatic screening on these properties of anionic (SLES) and zwitterionic (CapB) surfacta...

BACKGROUND Degenerative lumbar scoliosis (DLS) progresses with aging after 50-60 years, and the genetic association of DLS remains largely unclear. In this study, the genetic association between collagen type II alpha 1 (COL2A1) gene and DLS was investigated. METHODS COL2A1 gene polymorphism was investigated in DLS subjects compared to healthy controls to investigate the possibility of its as...

Degenerative lumbar scoliosis (DLS) progresses with aging after 50-60 years. The genetic association of DLS remains largely unclear. In this study, the genetic association between glutamate receptor, ionotropic, N-methyl D-aspartate (NMDA, GRIN) receptor genes and DLS was investigated. A total of 9 coding single nucleotide polymorphisms (cSNPs) in NMDA receptor genes [GRIN2A (rs8049651, Leu425L...

[D-Lys3]-Growth Hormone Releasing Peptide-6 (DLS) is widely utilized in vivo and in vitro as a selective ghrelin receptor (GHS-R) antagonist. This antagonist is one of the most common antagonists utilized in vivo to block GHS-R function and activity. Here, we found that DLS also has the ability to modestly block chemokine function and ligand binding to the chemokine receptor CCR5. The DLS effec...

Description Logics (DLs, for short) provide a logical reconstruction of the so-called frame-based knowledge representation languages. Originally, four-valued DLs have been proposed in order to develop expressively powerful DLs with tractable subsumption algorithms. Recently, four-valued DLs have been proposed as a model for (multimedia) document retrieval. In this context, the main reasoning ta...