dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. the aim of this study is to develop ocular dorzolamide hcl nanoliposomes (drz – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. nanoliposomes were prepared using reverse-phase evaporation vesicle (rev) and thin layer hydration (tlh...

PURPOSE To characterize the nyctohemeral rhythm of intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with newly diagnosed, untreated normal tension glaucoma (NTG). METHODS Twenty-seven patients with suspected NTG were prospectively included and underwent 24-hour monitoring of IOP and blood pressure (BP), polysomnography, and nailfold capillaropathy. The nyctohemeral r...

Introduction. Cataract surgery results in a reduction of intraocular pressure, but it has not been sufficiently investigated how affects short-term pressure fluctuations. The aim this study was to evaluate the effects cataract on fluctuations patients with primary angle-closure, or without glaucoma. Material and Methods. A prospective interventional clinical included 31 (eyes) angle-closure/pri...

The aim of the study was to evaluate the efficacy of replacing current dual local therapy (timolol and pilocarpine) with latanoprost 0.005% in 71 pseudoexfoliation glaucoma patients with controlled intraocular pressure (IOP). 39 patients switched to latanoprost 0.005%) and 32 patients continued timolol-pilocarpine therapy. Mean diurnal (IOP) was measured at baseline, after 0.5, 1, 3 and 6 month...

PURPOSE To evaluate how aging alters 24-hour measurements of intraocular pressure (IOP) in the sitting and supine body positions. METHODS Fifteen older volunteers with healthy eyes (ages, 53-71 years) were each housed for 1 day in a sleep laboratory. An 8-hour accustomed sleep period was assigned to each subject. Every 2 hours, measurements of IOP were taken in the sitting and supine position...

purpose: to evaluate the effect of intravitreal bevacizumab (ivb) injection on sustained intraocular pressure (iop) methods: this non-randomized prospective study was conducted on 359 eyes of 359 patients in amir almomenin (rasht) and labbafinejad (tehran) hospitals. after history taking and complete ocular examination, iop was measured one week and one day before injection (twice at each sessi...

purpose : to investigate intraocular pressure (iop) changes due to different serum level heights by using tonopen in acquired globes from the iran eye bank (ieb). methods : in this interventional prospective case series, serum were infused into 18 normal globes acquired from ieb by using 21g needle inserted in vitreal space through optic nerve head to change the iop by different fluid level hei...