BACKGROUND Pashanbhed is a commercially available diuretic and lithotropic drug, used to treat renal problems. It is a controversial name as it is assigned to various plants such as Bergenia ligulata, Kalanchoe pinnata, Coleus aromaticus and Rotula aquatica. OBJECTIVE To perform the comparative preliminary phytochemical screening, diuretic activity, and thin layer chromatography (TLC) finger ...

Hypoalbuminemic patients often have sufficient fluid accumulation to mandate diuretic therapy but are often resistant to diuresis. Studies have suggested that hypoalbuminemia itself impairs delivery of effective amounts of diuretic agent into the urine, the site of action. Therefore, administration of mixtures of albumin and loop diuretics may enhance responses. Thirteen patients with biopsy-pr...

S-8666, [6, 7-dichloro-5-(N, N-dimethylsulfamoyl)-2, 3-dihydrobenzofurancarboxylic acid] is a potent diuretic with uricosuric action. Although the major site of action of S-8666 has been proven by the in vitro microperfusion study to be the thick ascending limb of Henle's loop, clearance studies in the rat suggested that this drug has an additional thiazide-like action. To provide direct eviden...

Dh, the gene that encodes a CRF-like peptide in Drosophila melanogaster, is described. The product of this gene is a 44-amino-acid peptide (Drome-DH(44)) with a sequence almost identical to the Musca domestica and Stomoxys calcitrans diuretic hormones. There are no other similar peptides encoded within the known Drosophila genomic sequence. Functional studies showed that the deduced peptide sti...

background and objective: to assess the effectiveness and safety of oral amiloride for the treatment of edema in pediatric patients with idiopathic nephrotic syndrome. methods: a randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. the mean age was 4.3±0.7 years old. after a 2 week washout of diuretic therapy, nephrotic children with edema were randomized into two groups...

Hypertension (HTN) is a worldwide health problem and a major preventable risk factor for cardiovascular (CV) events. Achieving an optimal blood pressure (BP) target for patients with HTN will often require more than one BP-lowering drug. Combination therapy is not only needed, but also confers many advantages such as better efficacy and a better tolerability. A better compliance and simplicity ...

The Suffof-e-Suzak Qawi is an unani polyherbomineral formulation and is being used in the alternative system of medicine for its anti-gonorrheal and diuretic activity. It is an official monograph in national formulary of unani medicine-NFUM and reported as anti-gonorrheal and diuretic. The aqueous suspension of the formulation was studied for its possible diuretic activity, effect on urinary so...