The primary goal of this study was to assess peripheral bone microarchitecture and strength in postmenopausal women with type 2 diabetes with fragility fractures (DMFx) and to compare them with postmenopausal women with type 2 diabetics without fractures (DM). Secondary goals were to assess differences in nondiabetic postmenopausal women with fragility fractures (Fx) and nondiabetic postmenopau...

Purpose: The changes in the bone density of immature Sprague-Dawley (SD) rats whose sciatic nerve was cut were investigated to understand the patterns of bone density deterioration and to establish the rationale for preventive managements. Materials and methods: Eighteen six-day-old SD rats were randomly divided into the right sciatic neurectomy and sham-operation group. The trabecular bone den...

CONTEXT In healthy boys, fractures result from trauma of various severity, suggesting contribution of an intrinsic biomechanical fragility. OBJECTIVES Our objective was to characterize bone mineral mass, microstructure, and strength in boys with and without fractures. PARTICIPANTS AND DESIGN We followed 176 healthy boys from 7.4 ± 0.5 to 15.2 ± 0.5 (mean ± sd) yr of age. OUTCOMES Areal (a...

BACKGROUND Ankle valgus is a common deformity in patients with multiple hereditary exostoses (MHE) and a potential risk factor for early degenerative arthritis. In children, medial hemiepiphysiodesis of the distal tibia is a relatively simple surgical technique used to correct this deformity. We present here the first results of applying this procedure using the eight-Plate guided growth system...

Distal tibia fractures are frequently associated with an extensive soft tissue injury, leading to a higher risk of complications such as skin complications, infection, non-union, and eventually poor overall outcome. This study aims measure the outcome open/closed distal treated minimally invasive internal fixation. We aim propose algorithm for management by evaluating treatment options, outcome...

OBJECTIVES Overlap between the distal tibia and fibula has always been quoted to be positive. If the value is not positive then an injury to the syndesmosis is thought to exist. Our null hypothesis is that it is a normal variant in the adult population. METHODS We looked at axial CT scans of the ankle in 325 patients for the presence of overlap between the distal tibia and fibula. Where we th...

Osteoarthrosis (OA) is a multi-factorial disease characterized by the progressive loss of articular cartilage and the development subchondral sclerosis, intra-osseous cysts and osteophytes. In addition to changes in cartilage which occur in OA, it is suggested that early changes are seen in the adjoining subchondral and trabecular bone (1). In this work we develop, optimize and extend MR techni...

Botulism is a generalized paralyzing disease caused by the toxin of Clostridium botulinum (BTX). The toxin acts 3-4 days after injection by blocking the release of acetylcholine to the muscle. Six Wistar rats received a 2-U injection of BTX in the right quadriceps. Six rats were similarly injected with saline and were used as control. Paralysis of the quadriceps was obtained 4-5 days after the ...

Cricket nymphs have the remarkable ability to regenerate a functional leg following amputation, indicating that the regenerating blastemal cells contain information for leg morphology. However, the molecular mechanisms that underlie regeneration of leg patterns remain poorly understood. Here, we analyzed phenotypes of the tibia and tarsus (three tarsomeres) obtained by knockdown with regenerati...

STUDY DESIGN Retrospective cohort study. OBJECTIVES To determine if runners with a history of Achilles tendonopathy (AT) demonstrate a difference in transverse-plane motion and moments at the distal tibia and knee compared to runners without a history of AT. BACKGROUND One of the more prevalent overuse running injuries is AT. It has been hypothesized that prolonged pronation causes contradi...