A general model for the dissolution of stoichiometric particles in multi-component alloys is proposed and analysed. We introduce the concept of mass-conserving solutions and give a self-similar solution for the resulting Stefan-problem. Furthermore, we show that particle dissolution in multi-component alloys can under certain circumstances be approximated by a model for particle dissolution in ...

Different batches of atorvastatin, represented by two immediate release formulation designs, were studied using a novel dynamic dissolution apparatus, simulating stomach and small intestine. A universal dissolution method was employed which simulated the physiology of human gastrointestinal tract, including the precise chyme transit behavior and biorelevant conditions. The multicompartmental di...

Solubility of drug plays a prime role in controlling its dissolution from dosage form. Aqueous solubility of drug is a major factor that determines its dissolution rate. Minimum aqueous solubility of 1% is required to avoid potential solubility limited absorption problems. Studies of 45 compound of different chemical classes and a wide range of solubilities revealed that initial dissolution rat...

Dissolution mechanisms in porous media may lead to unstable dissolution fronts (“wormholing”). It has been shown in the literature that Darcy-scale models may reproduce all the characteristics of such dissolution patterns. This paper considers the core-scale averaged behavior of these Darcy-scale dissolution models. The form of core-scale equations is discussed based on the volume averaging of ...

The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus® (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...

The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus® (SOL)) prepared by different techniques. Dispersions of CLX in SOL at different ratios (2:1, 1:1, 1:2, 1:4 and 1:6) were prepared by spray drying, conventional solvent evaporation and melting metho...

the dried fruit of terminalia chebula is widely used for its laxative properties. the objective of the present study was to examine the flowability and compressibility of terminalia chebula fruit powder, subsequently developing its tablet formulations by utilizing wet granulation and direct compression technology. initial studies on flowability and compressibility revealed that the fruit powder...

[1] Dissolution of the surfaces of rock fractures can cause significant alteration of the fracture void space (aperture) and fracture permeability (k). Both surface reaction rates and transport of reactants within the fracture can limit local dissolution. We investigated the role of Peclet number (Pe), a measure of the relative importance of advective and diffusive transport of reactants, on fr...

Like many others, silicate solids dissolve when placed in contact with water. In a given aqueous environment, the dissolution rate depends on the composition and the structure of the solid and can span several orders of magnitude. Although the kinetics of dissolution depends on the complexities of both the dissolving solid and the solvent, a clear understanding of which structural descriptors o...