BACKGROUND The Prosody-Voice Screening Profile PVSP. A final section provides detailed (PVSP) is a perceptual procedure to assess a prosody-voice reference data for children with speaker's prosody and voice in conversational normal speech-language development and speech. The PVSP provides summative and children with speech-language disorders of per-utterance data on the appropriateness of known...

Proteins with wholly or partly denatured structures in vivo are called intrinsically disordered or natively unfolded proteins (NUPs). Functional importance of NUPs was revealed by NMR studies as first reviewed by P. Wright in 1999. Since then, computational analyses on NUPs have also been intensively carried out to predict that approximately one third of eukaryotic proteins are NUPs. I will sta...

A large segment of the proteome consists of disordered regions, yet in most cases, little is known about their mechanisms and functions. What are the roles of protein disorder in cell biology, and how do intrinsically disordered proteins function? These are the questions Cell's Robert Kruger posed to Madan Babu, Julie Forman-Kay, and Richard Kriwacki. Annotated excerpts from this conversation a...

Speech sound disorders are a common communication impairment in childhood. Because speech can negatively affect the lives and development of children, clinical intervention is often recommended. To help with diagnosis treatment, clinicians use instrumented methods such as spectrograms or ultrasound tongue imaging to analyse articulations. Analysis these be laborious for clinicians, therefore th...