Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease. In this study, to examine the protective efficacy of PCr against cerebral IR, disodium creatine phosphate was injected intravenously into rats before fo...

The chemical changes in the blood of dogs treated with various inorganic salts after obstruction of the duodenum are reported. Two dogs treated with sodium chloride survived approximately six times as long as the average untreated animal, one living 22 days, the other 24 days. Ammonium chloride was found to produce an acidosis. The administration of potassium chloride, calcium chloride, and mag...

Hyperpolarization turns weak nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) responses into strong signals, so normally impractical measurements are possible. We use parahydrogen to rapidly hyperpolarize appropriate 1H, 13C, 15N, and 31P responses of analytes (such as NH3) and important amines (such as phenylethylamine), amides (such as acetamide, urea, and methacrylamide)...

OBJECTIVES This study was performed to evaluate the effect of blood contamination on the compressive strength (CS) of Root MTA (RMTA) modified with Calcium chloride (CaCl2) and Disodium hydrogen phosphate (Na2HPO4) as setting accelerators over time. MATERIALS AND METHODS A total of 110 cylindrical specimens of RMTA were divided into 6 experimental groups as follows: Group1, RMTA; Group 2, RMT...

A simple, precise and rapid HPLC method has been developed for the simultaneous determination of Metformin and Vildagliptin in pharmaceutical dosage form. The method was carried out using Sunfire BDS C8 column (250 mm x 4.6 mm, 5 μm) and mobile phase comprised of disodium hydrogen phosphate pH 7.0±0.05 as buffer and acetonitrile in the ratio of 60:40 v/v and degassed under ultrasonication. The ...

The aim of the current study was to develop a simple, precise, and accurate capillary zone electrophoresis method for the determination of zolpidem tartrate in tablet dosage form. Separation was conducted in normal polarity mode at 25°C, 22 kV, using hydrodynamic injection for 10 s. Separation was achieved using a background electrolyte of 20 mM disodium hydrogen phosphate adjusted with phospho...

The main objective of the present work is to develop a new simple RPHPLC method for simultaneous estimation of Pioglitazone HCl and Glimepiride. A series of mobile phases were tried, among the various mobile phases 0.05 M Disodium hydrogen phosphate Buffer (pH 3± 0.2) Methanol and Acetonitrile in the ratio of 45:30:25 was found to be an ideal mobile phase since it gave a good resolution and pea...

Guizhou semi-fine wool sheep are affected by a disease, characterized by emaciation, lameness, stiffness in the gait, enlargement of the costochondral junctions, and abnormal curvature in the long bones. The objective of this study was to determine possible relationships between the disease and mineral deficiencies. Samples of tissue and blood were collected from affected and unaffected sheep. ...