Much remains uncertain about epileptic seizures in the context of Alzheimer's disease: pathogenesis, frequency, semiology, natural history, treatment. The authors suggest a pragmatic approach to developing the evidence base in order to inform decisions on seizure treatment, based on prior pragmatic studies in epilepsy.

As in many other chronic conditions, adherence to prophylactic treatment in migraine is probably poor. In chronic diseases, compliance at one year does not exceed 50%. That could explain the low therapeutic gain seen with migraine preventive medications. It also renders difficult the evaluation of clinical trials on migraine prophylaxis since in most of these trials compliance is not properly a...

BACKGROUND Assessing people's ability to drive has become a public health concern in most industrialized countries. Although age itself is not a predictive factor of an increased risk for dangerous driving, the prevalence of medical conditions that may impair driving increases with age. Because the implementation of a screening for unsafe driving due to medical conditions is a public health iss...

In accordance with the chronic disease model of opioid dependence, cessation is often observed as a longitudinal process rather than a discrete endpoint. We aimed to characterize and identify predictors of periods of heroin abstinence in the natural history of recovery from opioid dependence. Data were collected on participants from California who were enrolled in the Civil Addict Program from ...

BACKGROUND AND PURPOSE Approximately 9000 people in the UK are affected by Huntington's disease (HD). People with HD require ongoing health and social care support. There is a knowledge gap about costs of health and social care use associated with HD in the UK. This paper estimates the economic cost in the UK. METHODS Data on UK patients for the year 2013 were extracted from the European Hunt...

causes of the asthma epidemic, we are no closer to understanding it. As with other chronic diseases in which genetics and environment both clearly play a role, twin studies can be useful to address some of the challenges faced by epidemiologists that study allergic diseases, and asthma in particular. Among these are the lack of a specific phenotypic definition, the absence of simple means by wh...