G-protein coupled receptors (GPCRs) are a class of drug targets of primary importance. However, receptor assays are based on measurement of either ligand displacement or downstream functional responses, rather than direct observation of ligand binding. Issues of allosteric modulation, probe dependence, and functional selectivity create challenges in selecting suitable assays formats. Therefore,...

OBJECTIVE The purpose of this study was to verify the reproducibility between two different observers of an analysis method for diaphragmatic displacement measurements using direct visualization with videofluoroscopy. PATIENTS AND METHODS 29 mouth breathing children aged 5 to 12 years from both genders were analyzed. The diaphragmatic displacement evaluation was divided in three parts: videof...

Direct numerical simulation of turbulent channel flow over a compliant surface has been performed to evaluate the friction drag reduction effect. It is found that a slight drag reduction is observed over a compliant surface. This observation indicates that drag reduction is possible using a compliant surface that is deformed passively by wall pressure fluctuation. A small wall displacement and ...

By direct imaging we determine spin structure changes in Permalloy wires and disks due to spin transfer torque as well as the critical current densities for different domain wall types. Periodic domain wall transformations from transverse to vortex walls and vice versa are observed, and the transformation mechanism occurs by vortex core displacement perpendicular to the wire. The results imply ...

Early research on the mental health of civilians displaced by armed conflict focused primarily on the direct effects of exposure to war-related violence and loss. Largely overlooked in this war exposure model were the powerful effects of ongoing stressors related to the experience of displacement itself. An ecological model of refugee distress is proposed, drawing on research demonstrating that...

Restoration of the posterior maxilla with reduced bone height and pneumatized sinus is a challenge to the implant surgeon. The surgeon has the option of a direct sinus-lift approach or an indirect blind approach. Both of which have its own complications. Displacement of an implant into the maxillary sinus is rare occurrence and normally seen after the implant has been in service for a number of...

Different measures for lower limbs volume computation are available in clinical setting. These measures can be classified according to the equipment used and the data provided. Water displacement is considered the gold standard for limb volume measurement [1-3]. It is based on the Archimedes principle according to which the water volume moved by an object equals the object’s volume and it provi...

Direct interactive manipulation of 3D objects is very important in Computer Graphics. The user interface to deal with this problem poses a difficult problem because of the high number of degrees of freedom involved, associated with the loss of depth in the viewing projection. This paper introduces a new technique to specify displacement vectors in the three-dimensional space. The technique is b...