نتایج جستجو برای: diphtheria toxoid purification and characterization
تعداد نتایج: 16903098 فیلتر نتایج به سال:
The diphtheria epidemic in eastern Europe and the worldwide increase in diphtheria morbidity have sparked discussion on whether people in western Europe are adequately protected. 2 In western Europe, the effectiveness of long term protection afforded by immunisation programmes is under debate. In Belgium, the national immunisation programme against diphtheria was introduced in 1959. Vaccination...
Diphtheria toxoid-antitoxin precipitates formed in antitoxin excess can prepare guinea pigs, rats, and rabbits for a secondary type of antitoxin response. Priming may occur without the development of detectable serum antibody. In rats, toxoid-antitoxin precipitates are more efficient than "free" toxoid in priming, whereas in guinea pigs, the magnitude of the anamnestic response varies with the ...
The success encountered in the purification of tetanal toxin (1) and toxoid (2, 3), of diphtherial toxoid (4), and of soluble pertussal antigens (5) warranted attempts to purify other toxins and toxoids by the multiphase system of protein fractionation. The system employs the precise adjustment of methanol concentration, pH, ionic strength, and protein concentration under rigidly controlled con...
OBJECTIVES To describe the epidemiology of infant pertussis in King County, Washington, and to better understand the implications for tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination among older children, adolescents, and adults. DESIGN Retrospective analysis of reported pertussis cases among infants younger than 1 year, January 1, 2002, through December 3...
Background Maternal vaccination against group B Streptococcus (GBS) might provide protection against invasive GBS disease in infants. We investigated the kinetics of transplacentally transferred GBS serotype-specific capsular antibodies in the infants and their immune response to diphtheria toxoid and pneumococcal vaccination. Methods This phase 1b/2, observer-blind, single-center study (NCT0...
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