filariasis in dogs is caused by several species of filariids. because of importance of this infection in veterinary medicine and public health, it is necessary to carry out an epidemiological and cross sectional studies in various geographical areas and use of well-adapted diagnosis methods. in this study 205 capillary and whole blood samples were collected from doges in various counties of eas...

Iran is one of the endemic areas of Dirofilariasis, and also one of the most important zoonotic infections. Dirofilaria immitis causes a severe and fatal disease called heartworm disease in dog. It also produces pulmonary nodules in humans. The worm is to be investigated as a potential infection of humans and animals in various provinces in Iran. In this research, the samples were ...

background: the aim of the study was to determine the helminthic species occurring in great gerbil rhombomys opimus collected from maraveh tappeh, golestan province, northeast iran. methods : during 2010-2011, a total of 77 r. opimus were captured from rural areas of maraveh tap-peh, golestan province, using sherman live traps and examined for infectivity with any larva or adult stages of helmi...

ES-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae which is able to inhibit antigen receptor-stimulated proliferation of B and T lymphocytes in vitro and in vivo. The active component of ES-62 appears to be PC, as the results obtained with ES-62 are broadly mimicked by PC conjugated to bovine serum albumin or PC alone. Suc...

ES-62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that protects against ovalbumin (OVA)-induced airway hyper-responsiveness in mice by virtue of covalently attached anti-inflammatory phosphorylcholine (PC) residues. We have recently generated a library of small molecule analogues (SMAs) of ES-62 based around its active PC moiety as a starting point in novel drug...

The design and synthesis of a series of methyl 5(6)-substituted benzimidazole-2-carbamates as possible anthelmintics have been described. A rational analysis of the structural parameters which segregate the activity of resulting benzimidazole-2-carbamates against enteric and tissue dwelling helminths is presented. The influence of single and multiple spacers, which link the pharmacophores at 5(...

Between June and September 1944 there were 875 African soldiers admitted to the 37th General Hospital at Accra in the Gold Coast. Of these there were 10 who showed genital oedema in which filariasis was suspected. The oedema affected the penis in all of these patients and the scrotum also in 7 of them. On each an examination was made for microfilariae, by means of a day-and-night blood film to ...

Table of Contents 1 Introduction 1 1.1 Structure and function of chitinases 1 1.2 Filarial chitinases are potential targets for interventions 4 1.3 A. viteae as a model to investigate parasitological parameters of filarial diseases 6 1.4 Aims and objectives of the study 7 2 Results 9 2.1 Characterisation of A. viteae chitinase genes 9 2.1.1 Determination of the gene structure of A. viteae chiti...