lar keratoplasty is not new. Mühlbauer was the first to describe a technique for anterior lamellar keratoplasty (ALK) in 1840.1 Penetrating keratoplasty (PKP) has long been the standard treatment for severe corneal pathology. Lamellar surgery has endured significant technical challenges since its inception. The posterior corneal surface is invisible through an operating microscope, due to the s...

PURPOSE To investigate the incidence of adverse reactions after corneal transplantation, reported to the Eye Bank Association of America. METHODS Incidence of adverse reactions from January 1, 2007, to December 31, 2014, was analyzed. RESULTS Of the 354,930 transplants performed in the United States, adverse reactions were reported in 494 cases (0.139%). Primary graft failure (PGF) predomin...

JIP1 is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase-dependent JNK module. Results of earlier work led us to propose a model for JIP1-JNK complex regulation that predicts that under basal conditions, JIP1 maintains DLK in a monomeric, unphosphorylated, and catalytically inactive state. Upon appropriate module stimulation, JNK-JIP1 binding affinity...

A close relationship exists between adipocyte differentiation of stromal cells and their capacity to support hematopoiesis. The molecular basis for this is unknown. We have studied whether dlk, an epidermal growth factor-like molecule that intervenes in adipogenesis and fetal liver hematopoiesis, affects both stromal cell adipogenesis and B-cell lymphopoiesis in an established pre-B-cell cultur...

Nocardia keratitis occurred in 4 eyes of 3 patients (2 women and 1 man) who had photorefractive keratectomy (PRK) by the same surgeon at the same center. Two eyes of the first 2 patients required lamellar keratectomy to debulk the involved stroma and obtain specimens for microbiological and histopathological evaluation. Light microscopic examination disclosed gram-positive and acid-fast filamen...

The level of expression of dlk, an EGF-like protein possessing six EGF-like repeats in its extracellular region, is critical for 3T3-L1 fibroblasts to differentiate into adipocytes in response to IGF1. The mechanism of action of dlk is not well understood, but its localization on the cell membrane suggests that dlk may function as a receptor, as a ligand or as a regulatory protein modulating th...

purpose: to report 3 cases of nocardia keratitis following photorefractive keratectomy (prk). report of outbreak: four eyes of 3 patients (2 female and one male) who had undergone prk by a single surgeon at a single center developed nocardia keartitis 3 to 6 weeks postoperatively. mean age was 25 (range 23-28) years and mean onset of corneal manifestations was 29 (range 21-40) days after prk. c...