Fumarate-containing pharmaceuticals are potent therapeutic agents that influence multiple cellular pathways. Despite proven clinical efficacy, there is a significant lack of data that directly defines the molecular mechanisms of action of related, yet distinct fumarate compounds. We systematically compared the impact of dimethyl fumarate (DMF), monomethyl fumarate (MMF) and a mixture of monoeth...

15N nuclear magnetic resonance spectroscopy was used to follow the positional isotope exchange reaction of bovine liver argininosuccinate lyase. The enzyme was shown to catalyze the N-3-N-2 positional nitrogen exchange in [3-15N]argininosuccinate in the presence of excess arginase. The ratio of the positional isotope exchange rate and the rate for net substrate turnover is less than 0.15 at low...

The notion of extriangulated category was introduced by Nakaoka and Palu giving a simultaneous generalization exact categories triangulated categories. Our first aim is to provide an extension Auslander's formula: for some $\mathcal{C}$, there exists localization sequence $\operatorname{def}\mathcal{C} \to \mod\mathcal{C} \operatorname{lex}\mathcal{C}$, where $\operatorname{lex}\mathcal{C}$ den...

The Oxford Whole Body Counter was used to measure absorption from various therapeutic preparations of iron in five groups of subjects. Succinic acid enhanced absorption of iron when added to a solution of ferrous fumarate, but not when given with tablets of ferrous fumarate or ferrous sulphate. Ferrous fumarate plus ascorbic acid was absorbed better than ferrous fumarate alone but no better tha...

In [1] we present an extension of Prime Event Structures by a mechanism to express dynamicity in the causal relation. More precisely we add the possibility that the occurrence of an event can add or remove causal dependencies between events and analyse the expressive power of the resulting Event Structures w.r.t. to some well-known Event Structures from the literature. This technical report con...

The effects of halothane and diethyl ether on the regenerating liver following 70 per cent hepatectomy were studied in Fisher/344 (F) rats. Our aim was to discover whether halothane administered repeatedly and over prolonged periods could influence the liver regenerative process or hepatocyte function. We also wished to know if the effects of halothane differed from those of diethyl ether. We f...

In [1] we present an extension of Prime Event Structures by a mechanism to express dynamicity in the causal relation. More precisely we add the possibility that the occurrence of an event can add or remove causal dependencies between events and analyse the expressive power of the resulting Event Structures w.r.t. to some well-known Event Structures from the literature. This technical report con...