نتایج جستجو برای: diaphorase

تعداد نتایج: 1115  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
B J Day M Patel L Calavetta L Y Chang J S Stamler

Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O-(2)). NO synthase (NOS) has been shown to participate in PQ-induced lung injury. Current theory holds that NO reacts with O-(2) generated by PQ to produce the toxin peroxynitrite. We asked whether NOS might alternatively func...

Journal: :NeuroImage 1997
F Rivier S Clarke

The pattern of cytochrome oxidase, acetylcholinesterase, and NADPH-diaphorase activity was studied in the supratemporal plane, the posterior part of the superior temporal gyrus, and the insula of normal human brains. Five dark cytochrome oxidase regions were found: (i) on Heschl's gyrus (area TC of von Economo and Koskinas); (ii) on the planum polare (area TC/TG); (iii) posterior to Heschl's gy...

Journal: :Cancer research 1994
P J O'Dwyer K S Yao P Ford A K Godwin M Clayton

Resistance of hypoxic tumor cells to ionizing radiation and cytotoxic drugs has been attributed to changes in the reactivity and/or the half-times of reactive species in the altered redox environment. Exposure of eukaryotic cells to such hypoxic conditions results in the induction of the synthesis of several unrelated proteins. To investigate further the phenomenon of hypoxic cell resistance to...

Journal: :Cancer research 1972
S Fukuda N Yamamoto

4-Nitroquinoline 1-oxide (4NQO) damages bacterial genomes but not phage genomes. A reduction product of 4NQO, 4-hydroxyaminoquinoline 1-oxide (4HAQO), damages both the bacterial and phage genomes. These results imply that Salmonella typhimurium is able to convert 4NQO to 4HAQO and that 4HAQO reacts with the genomes. When phage P22 is treated with 4HAQO and assayed on S. typhimurium strains lyso...

Journal: :Carcinogenesis 1993
L M Parker D J Laurén B D Hammock B Winder D E Hinton

Biochemical and histochemical studies were conducted in aflatoxin B1-induced liver tumors in adult rainbow trout. Specific activities of the phase I enzymes, ethoxyresorufin-O-deethylase (EROD), microsomal and cytosolic epoxide hydrolase (mEH and cEH), aldehyde dehydrogenase (ALDH) and DT-diaphorase, and the phase II enzymes, gamma-glutamyltransferase (gamma-GT), glutathione transferase (GST) a...

Journal: :The Journal of veterinary medical science 2003
Takayuki Nakajima Yoshikuni Tanioka Kazuyuki Taniguchi

The principal center of the accessory olfactory system is the accessory olfactory bulb (AOB). In primates, simians are divided into two groups, New and Old World monkeys, and the AOB is present in only New World monkeys. The common marmoset (Callithrix jacchus) is a species of New World monkey. Although the morphology of the common marmoset AOB has been demonstrated, the distribution patterns o...

Journal: :Pharmacology, biochemistry, and behavior 2004
Gabriela Díaz-Véliz Sergio Mora Patricia Gómez Ma Teresa Dossi Juan Montiel Christian Arriagada Francisco Aboitiz Juan Segura-Aguilar

The purpose of this study was to evaluate the contribution of DT-diaphorase inhibition to in vivo neurodegenerative effects of dopamine (DA) oxidation to the corresponding o-quinones. The neurotoxicity to nigrostriatal DA neurons was induced by injection of manganese pyrophosphate (Mn(3+)) complex as a prooxidizing agent alone or together with the DT-diaphorase inhibitor dicumarol into the righ...

2006
Adenocarcinoma Cells P. J. O'Dwyer M. Clayton

Resistance of hypoxic tumor cells to ionizing radiation and cytotoxic drugs has been attributed to changes in the reacUvity and/or the half times of reactive species in the altered redox environment. Exposure of eukaryotic cells to such hypoxic conditions results in the induction of the synthesis of several unrelated proteins. To Investigate further the phe nomenon of hypoxic cell resistance to...

Journal: :Journal of anatomy 1998
R J Johnson M Schemann R M Santer T Cowen

Previous studies on ageing animal and human subjects have demonstrated a significant overall decline in neuronal numbers in the myenteric plexus of the enteric nervous system (ENS). Our study aimed to confirm this observation by counting myenteric neurons stained with the panneuronal markers PGP 9.5 and NADH-diaphorase. We also wished to examine the possibility that particular subpopulations of...

Journal: :Prague medical report 2006
V Riljak M Milotová K Jandová M Maresová J Pokorný S Trojan M Langmeier

Nicotine is a very widely used drug of abuse, which exerts a number of neurovegetative behavioural effects by interacting with the neuronal nicotinic acetylcholine receptor. Using histochemical analysis (NADPH-diaphorase and Fluoro-Jade B dye), the influence of intraperitoneal administration of nicotine on neurons of the hippocampus in 35-day-old male rats of the Wistar strain was studied. At t...

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