As the top-down fabrication techniques for silicon-based electronic materials have reached the scale of molecular lengths, researchers have been investigating nanostructured materials to build electronics from individual molecules. Researchers have directed extensive experimental and theoretical efforts toward building functional optoelectronic devices using individual organic molecules and fab...

Eight new amido functionalized reagents, L(1)-L(8), have been synthesized containing the sequence of atoms R(2)N-CH(2)-NR'-CO-R″, which upon protonation forms a six-membered chelate with a hydrogen bond between the tertiary ammonium N-H(+) group and the amido oxygen atom. The monocationic ligands, LH(+), extract tetrachloridometal(II)ates from acidic solutions containing high concentrations of ...

Seed treatment as a method of local application pesticides in precise agriculture reduces the amount used per unit area and is considered to be safest, cheapest most ecologically acceptable protecting seeds young plants from pests early stages their development. With introduction insecticides neonicotinoid group mid-1990s, frequency seed increased. Due suspected negative effects on pollinators,...

In the field of organic chemistry, a base is generally defined as a reagent capable of abstracting proton to yield a carbanion species. At a basic textbook level, organobases are normally limited to amines, which are categorized as very weak bases according to the above definition. The introduction of an imine function (1⁄4NH) to the a-carbon of amines affords more basic amine species, amidines...

Chlorantraniliprole (DPX-E2Y45, Rynaxypyr, Coragen) is a new compound by DuPont belonging to a new class of selective insecticides (anthranilic diamides) featuring a novel mode of action (group 28 in the IRAC classification). By activating the insect ryanodine receptors (RyRs) it stimulates the release and depletion of intracellular calcium stores from the sarcoplasmic reticulum of muscle cells...

A quantitative structure-activity relationship (QSAR) study has been carried out on a new series of tartrate-based compounds to explain their TNF-α converting enzyme (TACE) inhibition activity in terms of chemometric descriptors. The 2D-descriptors, identified through combinatorial protocol in multiple linear regression (CP-MLR) analysis, have highlighted the role of either polarizability or va...

A classical theory is developed which calculates the momentum transfer rate constant between an ion and a non-polar molecule. The model takes into consideration the effect of diffraction outside the capture limit on the rate constants. The theory is used to calculate momentum transfer rate constant for Cl- with trans-dichloroethylene and para-difluorobenzene. Theoretical results ...

Glycosylation is a common post-translational modification of proteins implicated in cellular recognition processes and controlling protein conformation.1 Typically, carbohydrates are O-linked to serine (Ser) and threonine (Thr) or N-linked to asparagine (Asn). Glycosylation of (2S,4R)-4-hydroxyproline (Hyp) is widespread in the plant kingdom and occurs in Hyp-rich glycoproteins (HRGPs) that are...

The fields of natural product total synthesis and combinatorial chemistry have major differences as well as much in common. Unique to combinatorial chemistry is the need to devise rapid and efficient methods for parallel synthesis and purification, while an area of overlap is the targeting of natural product scaffolds for combinatorial libraries. Both these aspects are illustrated with examples...

Yohimbine is a potent and selective 2versus 1-adrenoceptor antagonist. To date, drugs with high specificity for the 2-adrenoceptor show marginal selectivity among the three 2-adrenoceptor subtypes. Initial studies showed that yohimbine was about 4and 15-fold more selective for the human 2C-adrenoceptor in comparison with the 2Aand 2B-adrenoceptors, respectively. To improve on this 2-adrenocepto...