Renal failure is associated with an increased mcidence of hemorrhage from a variety of sites, particularly In patients undergoing surgical procedures. The primary factors in the pathogenesis of bleeding in renal failure are platelet biochemical abnormalities and alterations in platelet vessel wall interactions. Hemodialysis improves hemostatic abnormalities in uremia, but the need for hepariniz...

Anemia is the main problem for patients suffering from end stage renal disease (ESRD). This study aimed to determine whether the index of rigidity (IR), that shows red blood cells (RBCs) deformability and the possible IR disturbances can provide an explanation about the cause of anemia, in patients undergoing maintenance hemodialysis (HD) or on peritoneal dialysis. The IR was determined in 39 h...

OBJECTIVES Most studies on acute kidney injury (AKI) following open-heart surgery have focused on short-term outcome following coronary artery bypass grafting. We reviewed the incidence, risk factors and outcome, including long-term survival, of AKI after aortic valve replacement (AVR) in a population-based cohort. METHODS A retrospective review of 365 patients who underwent AVR for aortic st...

BACKGROUND Despite growing literature of the dialysis patients' high burden of illness and a compromised quality of life, little is known about their daily life experiences. METHODS A cross-sectional study using the day reconstruction method, an experience sampling method, was used. Seventy-one dialysis patients recruited from three dialysis centers systematically reconstructed their activiti...

Intraperitoneal (IP) vancomycin is widely used to treat Gram-positive peritonitis associated with peritoneal dialysis. There have been two cases of red man syndrome (RMS), a vancomycin-specific nonimmunologic reaction, associated with IP vancomycin. However, immune-mediated hypersensitivity reaction to IP vancomycin has not yet been reported. A 49 year old woman on continuous ambulatory periton...

To investigate the cause of clinically detectable splenomegaly, which is common in patients receiving regular haemodialysis, splenic volume was assessed by isotopic scanning using intravenously injected technetium-99m microspheres in 34 controls and 149 patients with chronic renal failure. Of the patients, 16 had never received dialysis, 10 were undergoing continuous peritoneal dialysis, 94 wer...

Available methods for the preparation of crystalline oxyhemoglobin may be divided into two groups, in the first of which alcohol or ether, or both, are used as aids to crystallization, and in the second of which the use of these solvents is avoided. Possible objections to the use of alcohol were early pointed out by Hiifner (l), and Mayet (2) emphasized the advantages of ‘(henzinc” over ether. ...

BACKGROUND Renal excretion is the primary route for the elimination of sugammadex. We evaluated the dialysability of sugammadex and the sugammadex-rocuronium complex in patients with severe renal impairment in the intensive care unit (ICU). METHODS Six patients in the ICU with acute severe renal impairment received general anaesthesia for transoesophageal echocardiography, to replace their tr...

Mechanization of the Bratton and Marshall procedure for the analysis of sulfonamides in biological fluids usually incorporated a dialysis step. Results for sulfamethoxazole and its major metabolite (N4-acetylsulfamethoxazole) by the traditional method of acid hydrolysis often showed “negative” quantities of the metabolite. After an exhaustive examination it was found that the dialysis step must...

Acute control of blood pressure on haemodialysis (HD) should be differentiated from chronic BP control; Hypertension in HD is multi-factorial; Patients requiring total ultrafiltration volume greater than 2.5 kg may have an elevation in pre-systolic and pre-diastolic BPs; Larger fluid removals of range >10-13ml/hour/kg are associated with increased all cause and cardiovascular mortality; Both pr...