background: the diagnosis of pulmonary tuberculosis (ptb) is complicated and time-consuming currently. there was association of ptb with serum tumor markers. in this study we aimed to evaluate the predictive role of serum ca125, ca199 and cea as diagnostic tools for ptb. methods: this study was designed as a case-control study with 565 subjects who visited the yijishan hospital from jun to dec ...

AIM OF THE STUDY To establish and evaluate the fingerprint diagnostic models of cerebrospinal protein profile in glioma with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) and bioinformatics analysis, in order to seek new tumor markers. MATERIAL AND METHODS SELDI-TOF-MS was used to detect the cerebrospinal protein bond to ProteinChip H4. The cereb...

BACKGROUND Various studies assessing the diagnostic value of serum tumor markers in patients with esophageal cancer remain controversial. This study aims to comprehensively and quantitatively summarize the potential diagnostic value of 5 serum tumour markers in esophageal cancer. METHODS We systematically searched PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI) and Chinese Bi...

INTRODUCTION Acute appendicitis is the most common abdominal emergency requiring emergency surgery. However, the diagnosis is often challenging and the decision to operate, observe or further work-up a patient is often unclear. The utility of clinical scoring systems (namely the Alvarado score), laboratory markers, and the development of novel markers in the diagnosis of appendicitis remains co...

Receiver operating characteristic (ROC) curves and in particular the area under the curve (AUC), are widely used to examine the effectiveness of diagnostic markers. Diagnostic markers and their corresponding ROC curves can be strongly influenced by covariate variables. When several diagnostic markers are available, they can be combined by a best linear combination such that the area under the R...

Exosomes carry abundant bioactive substances from parent cells, which contain tremendous protein and nucleic acid can be used as important diagnostic markers of diseases. In this work, we developed...

Receiver operating characteristic (ROC) curves are useful statistical tools for medical diagnostic testing. It has been proved its capability to assess diagnostic marker’s ability to distinguish between healthy and diseased subjects and to compare different diagnostic markers. In this paper we introduce non parametric ROC summary statistics to assess a ROC curve across the entire range of FPFs ...