Diabetic retinopathy is a common microvascular complication of diabetes mellitus and one the leading causes acquired blindness. Microalbuminuria reflects pathophysiological state vascular dysfunction organ damage. It noticed that rise in urinary albumin excretion seen early phase diabetic retinopathy. The concordance microalbuminuria has been well reported type 1 diabetes; however, for 2 diabet...

Angiotensin-converting enzyme (ACE) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. The present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (STZ)-diabetic rats treated for 4 weeks with nitro-L-arginine-methyl ester (L-NAM...

BACKGROUND Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparanase (HPA) is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, HPA enhances the phosphorylation of selected signaling m...

Diabetes can lead to various acute clinical complications, although the occurrence of ophthalmic signs and symptoms is uncommon. Neovascular glaucoma (NG), a rare complication associated with diabetes mellitus, one such condition. Additionally, anti-vascular endothelial growth factor (VEGF)-induced toxic anterior segment syndrome (TASS) intravitreal bevacizumab. In this case report, we present ...

Diabetic kidney disease (DKD) is a widespread chronic microvascular complication of diabetes mellitus (DM), affects almost 30-50% of patients, and represents a leading cause of death of DM. Serotonin or 5-hydroxytryptamine (5-HT) is a multifunctional bioamine that has crucial roles in many physiological pathways. Recently, emerging evidence from experimental and clinical studies has demonstrate...

Diabetic foot ulcers are a common manifestation of lesions on the diabetic foot, syndrome acquired as long-term complication diabetes mellitus. Accompanying neuropathy and vascular damage promote acquisition pressure injuries tissue death due to ischaemia. Affected areas prone infections, hindering healing progress. The research at hand investigates an approach classification infection ischaemi...

The patient who has a diagnosis of diabetes mellitus, diabetic peripheral neuropathy, peripheral vascular disease and experiences an unstable ankle fracture presents as a difficult case scenario for the treating physician. In addition, patients who have diabetes mellitus, along with the presence of multiple comorbidities, have been shown to have higher complication rates than patients who do no...

background: the most devastating manifestations of diabetes mellitus are vascular complications. although there are many factors involved in the pathogenesis of diabetic vasculopathy, many studies suggest a role for glucose–induced oxidative stress. studies in animal models, have demonstrated that the administration of antioxidants restores normal endothelial functions. the study was designed t...