This issue of Seminars in Vascular Surgery is devoted to the evaluation and management of lower-limb wounds in the vascular surgery patient. In-depth discussions of common clinical conditions are presented on the topics of venous ulcer, diabetic foot infection, peripheral arterial disease (PAD) with tissue loss, and surgical site infection (SSI). The first article by Scalise et al discusses the...

There is a high mortality in patients with diabetes and severe pressure ulcers. For example, chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1α). In diabetes, HIF-1α function is compromised by a high glucose-...

The number of people with diabetes worldwide was estimated at 131 million in 2000; it is projected to increase to 366 million by 2030.1 Previous studies have indicated that diabetic patients have up to a 25% lifetime risk of developing a foot ulcer.2 The annual incidence of diabetic foot ulcers is ~ 3%, and the reported incidence in U.S. and U.K. studies ranges as high as 10%.3 Once an ulcer ha...

OBJECTIVE Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer. In this study, the levels of lipid peroxides (LPO) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer ...

Background and objectives: Helicobacter pylori infection is suspected to be associated with extra-gastrointestinal disorders such as diabetes mellitus (DM). It still a subject of investigation whether H. has pathogenic role on DM or diabetic patients have an increased susceptibility infection. The aim the present study was find out rate in individuals without DM.
 Materials methods: conduc...

ABSTRAK DFU (Diabetic Foot Ulcer) adalah penyakit kaki penderita diabetes dengan karakteristik neuropati sensorik, motorik, otonom, gangguan makrovaskuler dan mikrovaskuler, perlu pendekatan multidisipliner untuk mengatasi terjadinya amputasi. Amputasi merupakan konsekuensi yang serius dari DFU. Sebanyak 14,3% akan meninggal dalam setahun setelah amputasi, sebanyak 37% 3 tahun pasca Menganalisi...

BACKGROUND: The coronavirus disease (COVID)-19 pandemic leads to significant changes in the healthcare system and undermining best practices for maintaining a diabetic limb. A large number of patients with foot are left without timely medical care at increased risk complications, hospitalization, lower limb amputation, death. new paradigm must be adopted transition from inpatient community-base...