BACKGROUND The present study evaluates the effects of extract of Musa sapientum fruit (MSE) on ulcer index, blood glucose level and gastric mucosal cytokines, TNF-α and IL-1β and growth factor, TGF-α (affected in diabetes and chronic ulcer) in acetic acid (AA)-induced gastric ulcer (GU) in diabetic (DR) rat. METHODS MSE (100 mg/kg, oral), omeprazole (OMZ, 2.0 mg/kg, oral), insulin (INS, 4 U/k...

Objective(s): The aim of this study was to observe the impact of sirolimus on proteinuria in streptozotocin (STZ) induced diabetic rats. Materials and Methods: Rats were given a single injection of STZ to induce diabetic rat model. Rats’ 24 hr urine was collected to test, urinary and the kidney tissues were harvested at the 8th and 20th weeks, respectively. Podocyte morphological changes were e...

Cardiac dysfunction is a severe secondary effect of Type 2 diabetes. Recruitment of the protein kinase B/glycogen synthase kinase-3 pathway represents an integral event in glucose homeostasis, albeit its regulation in the diabetic heart remains undefined. Thus the following study tested the hypothesis that the regulation of protein kinase B/glycogen synthase kinase-3 was altered in the myocardi...

Introduction Impaired diabetic wound healing is an important issue in diabetic complications. The present study aims to evaluate the protective effect on glycemic control against impaired diabetic wound healing using a diabetic rat model. We investigated the wound healing process and effect on the impaired wound repair by glycemic control in the Spontaneously Diabetic Torii (SDT) fatty rat, whi...

the methanolic extract of leaves of turnera ulmifolia l was evaluated for its effect on blood glucose in alloxan-induced diabetic and euglycemic rats. the extract were administered at three doses of 100, 200 and 400 mg/kg, p.o. glibenclamide (10 mg/kg, p.o.) was used as standard for control group. in euglycemic rat, extract were administered at three doses of 100, 200 and 400 mg/kg, p.o. extrac...

background: hyperlipidemia and oxidized-low-density lipoproteins (ox-ldl) are important independent cardiovascular risk factors that have been shown to stimulate vascular smooth muscle cell (vsmc) proliferation. the purpose of the present study was to investigate the effect of vitamin e on ox-ldl, lipid profile, c-reactive protein (crp), and vsmc proliferation of rat aorta. methods: male wistar...

introduction: zinc is an essential rare element that plays an important role in synaptic plasticity and modulation of the activity of central nervous system and is involved in learning and memory. increasing zinc intake may protect against conditions associated with zinc deficiency, such as diabetes. some studies have revealed that zinc deficiency in diabetic subjects is due to hogher excretion...

Progressive evolution of retinal vascular in diabetic retinopathy leads to blindness in up to 8,000 patients yearly. The major purpose of this investigation was to determine proton radiation dose response of the eye's retinal vasculature in the hypergalactosemia induced rat model of diabetic-like retinopathy and gain insight of possible role of proton radiotherapy in controlling diabetic retino...

AIM To evaluate diastolic function alterations of the right ventricle (RV) by echocardiography in type 2 diabetic rat models. MATERIALS AND METHODS Male Wistar rats were divided into 2 groups: a control group (n = 8) and a diabetic group (n = 16, with 11 remaining at the end of the experiment), which was fed a high-fat and high-calorie diet and injected with streptozotocin (STZ). RV diastolic...

The Spontaneously Diabetic Torii (SDT) rat is an inbred strain of Sprague-Dawley rat and recently is established as a nonobese model of type 2 diabetes (T2D). Male SDT rats show high plasma glucose levels (over 700 mg/dL) by 20 weeks. Male SDT rats show pancreatic islet histopathology, including hemorrhage in pancreatic islets and inflammatory cell infiltration with fibroblasts. Prior to the on...