Ziegler D. Treatment of diabetic neuropathy and neuropathic pain: how far have we come? Diabetes Care 2008;31(Suppl. 2): S255–S261. DOI: 10.2337/dc08-s263 Two tables and the text of this article were first published in “Ziegler D. Treatment of Diabetic Polyneuropathy: Update 2006. Annals of the New York Academy of Sciences 1084:250–266, 2006.” This article is therefore considered a duplicate pu...

Objective: Diabetic foot is one of the first cause lower extremity amputation. The aim this study to determine which nerve conduction disorders may be used predominantly for early diagnosis diabetic development in follow-up patients. 
 Material and Method: consists 3 different groups (150) patients diagnosed with type 2 diabetes (DM). 1. Group; 50 complications (DA+), 2. without polyneurop...

P atients in an open-label study had improvement in vibration detection threshold (VDT) as well as in their symptoms of diabetic polyneuropathy with fidarestat.1 The aldose reductase inhibitor (ARI) was tested in 22 type 2 diabetic patients, aged ≥20 years, with polyneuropathy and stable blood glucose control (mean HbA1c 7.2%). Patients had not used another ARI ≤3 months before baseline. For 28...

diabetes mellitus type ι is a metabolic disorder that affects multiple systems including the inner ear. patients with diabetes mellitus commonly complain about dizziness, floating sensation, tinnitus and sweating. the aim of this study was to compare vestibular evoked myogenic potentials (vemps) between diabetic patients with or without neuropathy. subjects included 14 patients with diabetes me...

Diabetes mellitus (DM) frequently affects the nervous system [1]. This holds true both for the peripheral and for the autonomic nervous system [2]. Diabetic polyneuropathy (or distal symmetrical polyneuropathy [DPN] or, simply, peripheral neuropathy) is the most common manifestation of DM in the nervous system [3, 4]. Of the autonomic nervous system, gastrointestinal autonomic neuropathy [5] an...

BACKGROUND To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats. METHODS The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and v...

Dr. Crésio Alves – Rua Plínio Moscoso 222 / 601 40157-190 Salvador BA Brasil. E-mail: [email protected] Chronic inflammatory demyelinating polyradiculopathy (CIDP) is an immune-mediated disorder for which specific clinical cerebrospinal fluid (CSF), electrophysiologic and histological criteria have been proposed. CIPD is an uncommon cause of childhood polyneuropathy. Descriptions of child...

Effective treatment of diabetic sensorimotor polyneuropathy remains a challenge. To assess the efficacy and safety of α-lipoic acid (ALA) over 20 weeks, we conducted a multicenter randomized withdrawal open-label study, in which 45 patients with type 2 diabetes and symptomatic polyneuropathy were initially treated with ALA (600 mg tid) for 4 weeks (phase 1). Subsequently, responders were random...

BACKGROUND Patients with diabetic polyneuropathy (DPN) are often confronted with ulceration of foot soles. Increased plantar pressure under the forefoot has been identified as a major risk factor for ulceration. This study sets out to test the hypothesis that changes in gait characteristics induced by DPN related muscle weakness are the origin of the elevated plantar pressures. METHODS Three ...

PURPOSE To evaluate the effect of diabetic polyneuropathy on choroidal thickness in type 2 diabetes patients. METHODS Forty-one diabetic polyneuropathy (DPN) patients with no or mild retinopathy, 50 non-DPN diabetic patients with no or mild retinopathy, and 42 healthy controls without any retinal complaint were included in the study. All participants underwent detailed ophthalmic examinations...