BACKGROUND Almost half of Diabetic Peripheral Neuropathies (DPNs) are symptom-free. Methods including questionnaires and electrodiagnosis (EDx) can be fruitful for easy reach to early diagnosis, correct treatments of diabetic neuropathy, and so decline of complications for instance diabetic foot ulcer and prevention of high costs. The goal of our study was to compare effectiveness of the Michig...

Botulinum toxin type A (BTX-A) is a potent neurotoxin that blocks acetylcholine release from presynaptic nerve terminals by cleaving the SNARE complex. BTX-A has been reported to have analgesic effects independent of its action on muscle tone. The most robust results have been observed in patients with neuropathic pain. Neuropathic pain due to peripheral lesions has been the most widely studied...

Description of Procedure or Service Quantitative sensory testing (QST) systems are used for the noninvasive assessment and quantification of sensory nerve function in patients with symptoms of or the potential for neurologic damage or disease. Pain conditions evaluated may include diabetic neuropathy and uremic and toxic neuropathies, complex regional pain syndrome, carpal tunnel syndrome, and ...

Neuropathic pain is a common symptom in the elderly and tends to increase according frequency of related underlying disease. In older patients, cognitive decline accompanying medical conditions may make early diagnosis difficult. Therefore, detailed history taking, neurological examination, laboratory tests should be performed. Diabetic peripheral neuropathy, entrapment radiculopathy, postherpe...

Peripheral neuropathies (PN) in older adults often involve altered vibrational perception, i.e. hypopallesthesia. The main objective of this cross-sectional study was to determine whether age-related lower-limb hypopallesthesia is associated with a history falls cognitively intact non-diabetic adults. population comprised 157 people (mean, 71.5 ± 3.8years, 45.3 % female, 19.7 falls). Fallers mo...

It is estimated that between 2010 and 2030 there will be a 98% increase in the number of adults in sub-Saharan Africa with diabetes.1 This is just one aspect of the epidemic of non-communicable diseases facing subSaharan Africa, driven by urbanisation, ageing, and changes to lifestyle and environment. The diabetes epidemic poses a significant challenge to health services, as non-communicable co...

Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada R3E 3P4 Phoenix Pharmaceuticals Inc., Burlingame, CA 94010, USA Ruian Center of Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China Department of Endocrinology andMetabolism, The First Affiliated Hospital, WenzhouMedical Univers...