OBJECTIVE To validate the Archimedes model of diabetes and its complications for a variety of populations, organ systems, treatments, and outcomes. RESEARCH DESIGN AND METHODS We simulated a variety of randomized controlled trials by repeating in the model the steps taken for the real trials and comparing the results calculated by the model with the results of the trial. Eighteen trials were ...

Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin that it produces. The number of people with diabetes is increasing. These trends highlight the urgency for a better understanding of diabetes as well as for improving the dental care of patients with diabetes. Patients with diabetes have increased frequ...

Before the introduction of insulin in 1922 treatments for diabetes mellitus relied mainly on dietary measures including traditional medicines derived from plants. During this century the dietary recommendations for diabetes have turned full circle, with the renewed appreciation that carbohydrate-rich high-fibre diets can benefit the control of glycaemia and improve certain diabetic complication...

Previously we have demonstrated that diabetes causes impairment in vascular function of epineurial vessels, which precedes the slowing of motor nerve conduction velocity. Treatment of diabetic rats with aldose reductase inhibitors, aminoguanidine or myo-inositol supplementation have been shown to improve motor nerve conduction velocity and/or decreased endoneurial blood flow. However, the effec...

IN BRIEF There has been a concurrent dramatic rise in type 2 diabetes and dementia in the United States, and type 2 diabetes shares common genetic and environmental risk factors and underlying pathology with both vascular and Alzheimer's dementias. Given the ability to identify this at-risk population and a variety of potential targeted treatments, type 2 diabetes represents a promising focus f...

Aim: Many traditional treatments have been recommended in the alternative system of medicine for treatment of diabetes mellitus. Juglans regia is one of the medicinal plants used in traditional Iranian medicine as a treatment for diabetes, but little scientific documentation supports its antidiabetic action. Th e purpose of this study was to investigate antidiabetic eff ect of J. regia leaves i...

BACKGROUND Diabetes is impacting more and more people each year. A key aspect of disease management is patient adherence to prescribed treatments. Treatment adherence is influenced by many factors, including the understanding of a treatment's benefits and risks. OBJECTIVE This study sought to describe the experience of benefit and risk assessment for people with type 2 diabetes when making tr...

Hispanics in the United States have a disproportionately high risk for non-insulin-dependent diabetes mellitus (type 2 diabetes) compared with non-Hispanic whites. Little is known of the attitudes and beliefs about diabetes in this group. Using data from six focus groups of 42 Mexican Americans (14 men and 28 women), we characterized perceptions about the causes of and treatments for type 2 dia...