A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalat...

The widespread use of plastic bags in routine blood bank procedures has been attended by concern about the accumulation of substances from the plastic containers in the blood products and the biologic effects of these substances (1-11). Most poly(vinyl chloride) plastic bags contain di-2-ethylhexyl phthalate (DEHP) to make them pliable enough to prevent breakage (2, 5). This material has been s...

Di(2-ethylhexyl)phthalate (DEHP) was administered to male rats in the diet at concentrations of 2.0, 0.2, and 0.02% for up to 102 weeks. Low doses resulted in moderate increases in certain hepatic enzymes during the initial phase of exposure and in a continuous increase in the activities of these same enzymes throughout the treatment period. An increased level of dolichol and decreased concentr...

The Ames assay was used to investigate the mutagenicity of several phthalate esters as an approximation of their carcinogenic potential. The ortho diesters, dimethyl phthalate (DMP) and diethyl phthalate (DEP) produced a positive dose-related mutagenic response with Salmonella TA100, but only in the absence of S-9 liver enzymes. Dibutyl, di(2-ethylhexyl), mono(2-ethylhexyl), and butyl benzyl ph...

essential oils are considered as very complex natural mixtures containing numerous components at quite various concentrations. lythrum salicaria has not been previously subjected to examination of its volatile oil. the present study was carried out to evaluate the essential oil composition of the flowering aerial parts of the plant by using conventionally hydro-distillation (hd) and microwave a...

It has become increasingly evident in recent years that the dialkyl phthalate esters are widely distributed in our environment (1-4). As an explanation of this wide distribution there are many possible pathways by which these chemicals can be introduced into the human body. Jaeger and Rubin (5) have shown that di-2-ethylhexyl phthalate (DEHP) can be found in the tissues of patients who have rec...

Oils extracted from plants have been used since ancient times and in many cultures .frying oils are used in many countries all around the world including Iran. Therefore it is of great importance to ensure the safety of these food products which are usually delivered in polyethylene terephthalate (PET) bottles. This study has investigated the effect of storage time and temperature on the migrat...

Phthalate diesters have been shown to be developmental and reproductive toxicants in animal studies. A recent epidemiologic study showed certain phthalates to be significantly associated with reduced anogenital distance in human male infants, the first evidence of subtle developmental effects in human male infants exposed prenatally to phthalates. We used two previously published methods to est...