The chemical composition variations of the Indian mackerel (Rastrelliger kanagurta) from Karachi coast were investigated seasonally over the period of one year (2004-2005).  Moisture, crude protein, fat and ash contents varied from 70.11-74.41%, 16.02- 20.09%, 3.0-12%, and 0.89-1.35% respectively. The seasonal data indicated that the main fatty acids of the total lipid were C16:0, C16:1, C18:0,...

In this study, seasonal variations of total fatty acid (FA), phospholipid (PL) and triacylglycerol (TAG) compositions in liver tissues catfish (Silurus triostegus) were investigated. Samples S. triostegus obtained from Atatürk Dam Lake, Turkey, two month periods during one year as May. The major components palmitic (16:0), stearic (18:0), oleic (18:1n-9), palmitoleic (16:1n-7), docosahexaenoic...

Mitsohiro Yokohama and colleagues 1 noted that non-fatal coronary events, but not cardiac deaths, were lower in hypercholesterolaemic Japanese patients who were given 1800 mg per day of the omega 3 fatty acid eicosapentaenoic acid (EPA) than in controls. At first, these results seem to contrast with other published data which indicate that omega 3 fatty acid preparations, including the end prod...

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) protect against cardiovascular disease by largely unknown mechanisms. We tested the hypothesis that EPA and DHA may compete with arachidonic acid (AA) for the conversion by cytochrome P450 (CYP) enzymes, resulting in the formation of alternative, physiologically active, metabolites. Renal and hepatic microsomes, as well as various CYP i...

Blood levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been related to coronary heart disease risk. Understanding the response of EPA + DHA in blood to dietary intake of EPA + DHA would facilitate the use of blood measures as markers of adherence and enable the development of dietary recommendations. The objective of this study is examine the blood response to intakes o...

Several studies have implicated the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in inhibition of normal platelet function, suggesting a role for platelets in EPA- and DHA-mediated cardioprotection. However, it is unclear whether the cardioprotective mechanisms arise from alterations to platelet-platelet, platelet-matrix, or platelet-coagulation factor interact...

PURPOSE To provide an overview of prescription and dietary supplement omega-3 fatty acid (OM3-FA) products and considerations for clinical use. DESIGN Narrative review. METHODOLOGY The PubMed database was searched for cardiovascular-related investigations focused on eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) (limit: English-only articles). Additional regulatory informatio...

Atopic dermatitis (AD) is caused by both dysregulated immune responses and an impaired skin barrier. Although leukotriene B4 (LTB4) is involved in tissue inflammation that occurs in several disorders, including AD, therapeutic strategies based on LTB4 inhibition have not been explored. Here we demonstrate that progression of an AD-like skin disease in NC/Nga mice is inhibited when docosahexaeno...

Brain eicosapentaenoic acid (EPA) levels are 250- to 300-fold lower than docosahexaenoic acid (DHA), at least partly, because EPA is rapidly β-oxidized and lost from brain phospholipids. Therefore, we examined if β-oxidation was necessary for maintaining low EPA levels by inhibiting β-oxidation with methyl palmoxirate (MEP). Furthermore, because other metabolic differences between DHA and EPA m...

b a ckground:  scientific literature has shown evidence that omega-3 polyunsaturated  fatty  acids  (pufa)  have  anti-androgenic  action,  and  for  this reason could be useful as an adjuvant in hyperandrogenism conditions including polycystic ovarian syndrome (pcos). however, the possible effect of eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) supplementation on testosterone conc...