نتایج جستجو برای: dgcr8
تعداد نتایج: 347 فیلتر نتایج به سال:
Canonical microRNA biogenesis requires the Microprocessor components, Drosha and DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The Microprocessor is not required for processing of some miRNAs, including mirtrons, in which spliceosome-excised introns are direct Dicer substrates. In this study, we examine the processing of putative human mirtrons and demonstrate that althoug...
MicroRNAs are currently being extensively studied due to their important role as post-transcriptional regulators. During miRNA biogenesis, precursors undergo two cleavage steps performed by Drosha-DGCR8 (Microprocessor) cleaving of pri-miRNA to produce pre-miRNA and Dicer-mediated cleaving to create mature miRNA. Genetic variants within human miRNA regulome have been shown to influence miRNA ex...
RATIONALE Heart failure is a deadly and devastating disease that places immense costs on an aging society. To develop therapies aimed at rescuing the failing heart, it is important to understand the molecular mechanisms underlying cardiomyocyte structure and function. OBJECTIVE microRNAs are important regulators of gene expression, and we sought to define the global contributions made by micr...
Ruben D. Acosta, MD, Neena S. Abraham, MD, MSCE, FASGE (invited content expert, ad-hoc member), Vinay Chandrasekhara, MD, Krishnavel V. Chathadi, MD, Dayna S. Early, MD, FASGE, Mohamad A. Eloubeidi, MD, MHS, FASGE, John A. Evans, MD, Ashley L. Faulx, MD, FASGE, Deborah A. Fisher, MD, MHS, FASGE, Lisa Fonkalsrud, BSN, RN, CGRN, Joo Ha Hwang, MD, PhD, FASGE, Mouen A. Khashab, MD, Jenifer R. Light...
Mouen A. Khashab, MD, Shabana F. Pasha, MD, V. Raman Muthusamy, MD, FASGE, Ruben D. Acosta, MD, David H. Bruining, MD, Vinay Chandrasekhara, MD, Krishnavel V. Chathadi, MD, Mohamad A. Eloubeidi, MD, MHS, FASGE, Robert D. Fanelli, MD, FACS, FASGE, SAGES Representative, Ashley L. Faulx, MD, FASGE, Lisa Fonkalsrud, BSN, RN, CGRN, SGNA Representative, Suryakanth R. Gurudu, MD, FASGE, Loralee R. Kel...
Daniel F Gudbjartsson1, G Bragi Walters1, Gudmar Thorleifsson1, Hreinn Stefansson1, Bjarni V Halldorsson1,2, Pasha Zusmanovich1, Patrick Sulem1, Steinunn Thorlacius1, Arnaldur Gylfason1, Stacy Steinberg1, Anna Helgadottir1, Andres Ingason1, Valgerdur Steinthorsdottir1, Elinborg J Olafsdottir3, Gudridur H Olafsdottir3, Thorvaldur Jonsson4, Knut Borch-Johnsen5,6, Torben Hansen5, Gitte Andersen5, ...
Vinay Chandrasekhara, MD, Krishnavel V. Chathadi, MD, Ruben D. Acosta, MD, G. Anton Decker, MBBCh, MRCP, MHA, Dayna S. Early, MD, Mohamad A. Eloubeidi, MD, John A. Evans, MD, Ashley L. Faulx, MD, Robert D. Fanelli, MD, SAGES Representative, Deborah A. Fisher, MD, MHS, Kimberly Foley, RN, BSN, CGRN, SGNA Representative, Lisa Fonkalsrud, BSN, RN, SGNA Representative, Joo Ha Hwang, MD, PhD, Terry ...
museum of foods, drugs and instruments in which by far the most prominent and artistic exhibit was that of Messrs. Burroughs, Wellcome & Co., with its offshoots upon which the Fairchild Digestive Ferments and Wyeth Beef Juice were shown. The height of perfection to which the manufacture of "tabloids" has been carried was well shown by the examples exhibited, including Cascara, Quinine, Voice, B...
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