We have compared the renal effects of ketorolac trometamol 10 mg administered 4-hourly by intermittent i.m. injection or by continuous i.m. infusion with placebo in a double-blind study in 67 patients who had undergone upper abdominal surgery. Ketorolac was supplemented during the 48-h postoperative study period with bolus doses of morphine delivered by a patient controlled analgesia system. Th...

BACKGROUND Gemcitabine is a potent cytotoxic agent used in the treatment of many solid tumours, sarcomas and lymphomas. Vascular toxicity and thrombotic events related to gemcitabine seem to be underreported. CASE REPORT We report two cases of gemcitabine related digital ischemic events. Case 1. A 65-year-old man was given the first-line treatment with gemcitabine for the advanced adenocarcin...

Ketoprofen, (RS) 2-(-benzoylphenyl)-propionic acid (C16H14O3), is an arylpropionic acid derivative belonging to the nonsteroidal anti-inflammatory drug family. Synthesized by Rhone-Poulenc SA in the 1960s and marketed internationally since 1973, the drug is used mainly for the treatment of musculoskeletal diseases because of its anti-inflammatory and analgesic properties. It is frequently the c...