PURPOSE The aims of this study were to investigate the efficacy of combining the systematized behavioral modification program (SBMP) with desmopressin therapy and to compare this with desmopressin monotherapy in the treatment of nocturnal polyuria (NPU). METHODS Patients were randomized at 8 centers to receive desmopressin monotherapy (group A) or combination therapy, comprising desmopressin ...

A 20 years old woman, admitted in our Centre at the 6th week of pregnancy, was affected by Central Diabetes Insipidus and since the age of 10 years old she assumed desmopressin at a dose of 30 mg/nostril/day. She was primigravida, with normal past medical history. Fasting blood levels were normal; specific gravity of the urine: 1006; no glucosuria or proteinuria was present. Urinary and plasma ...

Introduction. The secondary increase in the size of intracranial haematomas as a result of spontaneous haemorrhage or trauma is of particular relevance in the event of prior intake of platelet aggregation inhibitors. We describe the effect of desmopressin acetate as a means of temporarily stabilising the platelet function. Patients and Methods. The platelet function was analysed in 10 patients ...

Desmopressin is used to treat primary nocturnal enuresis in children. Over the years, various formulations of desmopressin were commercialized of which the sublingual melt tablet is preferred in the pediatric population, despite the lack of full PK studies in this population. A full PK study was performed in growing conventional piglets to evaluate if this juvenile animal model can provide supp...

Purpose: To study the safety and efficacy of intranasal desmopressin and intramuscular tramadol versus pethidine for treatment of renal colic. Materials and Methods: A total of 90 adult patients who presented with renal colic to the emergency wards were recruited in this study. The patients were randomly assigned to receive 100 mg intramuscular tramadol, 40 μg intranasal desmopressin, or 40 μg ...

objective: to compare the efficacy of desmopressin (ddavp), tramadol and indomethacin on pain intensity of patients with acute renal colic caused by urolithiasis. m et h o d s : this prospective, randomized clinical trial was conducted between july 2005 and july 2006 including 120 patients (70 men and 50 women, mean age 38.2±5.8 years) referring to emergency room of shahid faghihi hospital with...